Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 1,520.00 | |
50 mg | Inquiry | $ 1,980.00 | |
100 mg | Inquiry | $ 2,500.00 |
Description | Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1]. |
In vitro | Physachenolide C, at concentrations ranging from 0.01-10 μM over a 48-hour period, impedes the proliferation of Yale University Mouse Melanoma (YUMM) cell lines YUMM2.1 and YUMMER1.7, exhibiting half-maximal inhibitory concentration (IC50) values of 0.5159 μM and 1.8230 μM, respectively. Concurrently, this compound markedly elevates the population of early-stage apoptotic cells and induces cell cycle arrest at the G0-G1 phase [1]. |
In vivo | Physachenolide C, administered intratumorally at a dose of 20 mg/kg daily for 15 consecutive doses, markedly suppressed tumor growth and induced complete regression of tumors in a murine melanoma model, without notable toxicity in the mice. Furthermore, treatment with Physachenolide C resulted in a significant elevation in the proportion of TUNEL-positive cells, reaching 40%, indicating enhanced apoptotic activity [1]. |
Molecular Weight | 544.63 |
Formula | C30H40O9 |
CAS No. | 791117-61-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Physachenolide C 791117-61-8 Chromatin/Epigenetic Epigenetic Reader Domain inhibitor inhibit