Cholecystokinin-33 (swine), a fragment of cholecystokinin (CCK), can reduce food intake and induce gallbladder contraction [1].

Cholecystokinin-33 (swine, 0.05-0.25 nM/kg; catheterization, for a branch of the abdominal aorta and a branch of the aorta located caudal) specifically targets gastrointestinal sites to regulate feeding behaviors in male Sprague Dawley rats (400-450 g). This compound has been shown to decrease meal size (MS) and enhance the satiety ratio (SR) when administered at sites served by the cranial mesenteric artery [1]. The administered dosages were 0.05, 0.15, and 0.25 nM/kg, demonstrating its effectiveness in reducing food intake and increasing satiation at these specific arterial sites.