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Isoxicam
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Catalog No. T0285Cas No. 34552-84-6
Alias Maxicam, Isoxicamum, Isoxicamo
Isoxicam (Isoxicamum) is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
Isoxicam
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Purity: 99.02%
Catalog No. T0285Alias Maxicam, Isoxicamum, IsoxicamoCas No. 34552-84-6
Isoxicam (Isoxicamum) is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $30 | In Stock | In Stock | |
| 50 mg | $40 | In Stock | In Stock | |
| 100 mg | $64 | - | In Stock | |
| 200 mg | $108 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.02%
Color:White to Yellow
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Product Introduction
Isoxicam AI Summary
Isoxicam demonstrates a broad range of pharmacological and bioactivity profiles, including significant antiinflammatory effects, enzyme inhibition, and moderate antiviral activity. It exhibits antiinflammatory activity in models such as carrageenan-induced rat paw edema and adjuvant-induced polyarthritis, with effective doses ranging from 1.56 mg/kg to 12.5 mg/kg. The compound inhibits human Prostaglandin G/H synthase 2 and 1, with the highest inhibition observed at concentrations of 1 µg/mL and 10 µg/mL, respectively. Despite its high oral bioavailability and complete absorption in humans, it shows limited renal and hepatic clearance. Its total body clearance rate is 0.07 mL/min/kg, and it has a high volume of distribution at steady state, suggesting good tissue penetration.
In vitro, Isoxicam is inactive against ovine COX-1 at 200 µM, but it shows various bioactivities such as modulating Lamin A splicing and inhibiting Ubiquitin-specific Protease USP2a, lipid storage, Histone Lysine Methyltransferase G9a, HP1-beta Chromodomain interactions, Polymerase Iota, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It also exhibits antiviral activities, including blocking Ebola virus entry and inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells.
Pharmacokinetic studies reveal a mean residence time of 44 hours and a half-life of 33 hours after intravenous administration. Isoxicam binds strongly to human serum albumin (80.4% to 97.3%) and interacts with the binding sites, potentially displacing radiolabeled compounds. It inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected cells and shows no significant inhibition of human BSEP, MRP2, MRP3, and MRP4.
While Isoxicam demonstrates moderate activity in some assays, including inhibition of human HDAC6 and SARS-CoV-2 3CL-Pro protease, it is categorized as DILI negative according to the Drug Induced Liver Injury Prediction System. The overall profile indicates a compound with substantial antiinflammatory properties, broad enzyme inhibition capabilities, notable antiviral potential, and favorable pharmacokinetics and bioavailability..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Isoxicam (Isoxicamum) is a non-steroidal anti-inflammatory drug that is not marketed in the United States. |
| Synonyms | Maxicam, Isoxicamum, Isoxicamo |
| Molecular Weight | 335.34 |
| Formula | C14H13N3O5S |
| Cas No. | 34552-84-6 |
| Smiles | OC=1C=2C(S(=O)(=O)N(C)C1C(NC3=NOC(C)=C3)=O)=CC=CC2 |
| Relative Density. | 1.588 g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.36 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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