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Anti-inflammatory agent 50

Catalog No. T79585

Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and TNF-α. It mitigates acute lung injury by modulating these mediators and suppressing the MAPK, NF-κB, and NLRP3 inflammasome signaling pathways [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Anti-inflammatory agent 50 Chemical Structure

Anti-inflammatory agent 50, CAS N/A

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Biological Description

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Description	Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and TNF-α. It mitigates acute lung injury by modulating these mediators and suppressing the MAPK, NF-κB, and NLRP3 inflammasome signaling pathways [1].
In vitro	In LPS-stimulated RAW264.7 cells, Anti-inflammatory agent 50 (compound a1) inhibits inflammatory mediators including nitric oxide (NO) with an IC50 of 3.26 μM, interleukin-6 (IL-6) with an IC50 of 1.85 μM, and tumor necrosis factor-alpha (TNF-α) with an IC50 of 3.88 μM. Additionally, Anti-inflammatory agent 50 significantly suppresses the expression of certain immunorelated cytotoxic factors, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) [1].
In vivo	Anti-inflammatory agent 50 (compound a1) mitigates pulmonary inflammation and decreases levels of NO, IL-6, TNF-α, COX-2, and iNOS in mice suffering from LPS-induced acute lung injury (ALI). It acts by attenuating the phosphorylation of p38 MAPK, c-JNK, and ERK, thereby inhibiting the mitogen-activated protein kinase (MAPK) signaling pathway. Furthermore, Anti-inflammatory agent 50 inhibits the activation of the NF-κB signaling pathway by preventing the phosphorylation of inhibitor of NF-κB alpha (IκBα) [1].

Molecular Weight	673.88
Formula	C40H55N3O6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Anti-inflammatory agent 50 NF-Κb NF-κB inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.