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Val-Ala-PABC-Exatecan

Name: Val-Ala-PABC-Exatecan
Brand: TargetMol
SKU: T77849
Rating: 4.5 (1 reviews)

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Catalog No. T77849Cas No. 2845164-91-0

Val-Ala-PABC-Exatecan is a drug-linker conjugate comprising the cleavable linker Tesirine and the topoisomerase I inhibitor Exatecan, used in synthesising antibody-drug conjugates (ADCs).

Val-Ala-PABC-Exatecan

😃Good

Catalog No. T77849Cas No. 2845164-91-0

Val-Ala-PABC-Exatecan is a drug-linker conjugate comprising the cleavable linker Tesirine and the topoisomerase I inhibitor Exatecan, used in synthesising antibody-drug conjugates (ADCs).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	8-10 weeks	8-10 weeks
5 mg	$88	8-10 weeks	8-10 weeks
10 mg	$132	8-10 weeks	8-10 weeks
25 mg	$252	8-10 weeks	8-10 weeks
50 mg	$429	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Val-Ala-PABC-Exatecan is a drug-linker conjugate comprising the cleavable linker Tesirine and the topoisomerase I inhibitor Exatecan, used in synthesising antibody-drug conjugates (ADCs).

Chemical Properties

Molecular Weight	754.80
Formula	C₄₀H₄₃FN₆O₈
Cas No.	2845164-91-0
Smiles	N(C(OCC1=CC=C(NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)C=C1)=O)[C@@H]2C3=C4C(C=5N(C4)C(=O)C6=C(C5)[C@](CC)(O)C(=O)OC6)=NC=7C3=C(CC2)C(C)=C(F)C7
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (105.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3249 mL	6.6243 mL	13.2485 mL	66.2427 mL
5 mM	0.2650 mL	1.3249 mL	2.6497 mL	13.2485 mL
10 mM	0.1325 mL	0.6624 mL	1.3249 mL	6.6243 mL
20 mM	0.0662 mL	0.3312 mL	0.6624 mL	3.3121 mL
50 mM	0.0265 mL	0.1325 mL	0.2650 mL	1.3249 mL
100 mM	0.0132 mL	0.0662 mL	0.1325 mL	0.6624 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc