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Val-Ala-PABC-Exatecan

Name: Val-Ala-PABC-Exatecan
Brand: TargetMol
SKU: T77849
Rating: 4.5 (1 reviews)

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Catalog No. T77849Cas No. 2845164-91-0

Val-Ala-PABC-Exatecan is a drug-linker conjugate comprising the cleavable linker Tesirine and the topoisomerase I inhibitor Exatecan, used in synthesising antibody-drug conjugates (ADCs).

Val-Ala-PABC-Exatecan

😃Good

Catalog No. T77849Cas No. 2845164-91-0

Val-Ala-PABC-Exatecan is a drug-linker conjugate comprising the cleavable linker Tesirine and the topoisomerase I inhibitor Exatecan, used in synthesising antibody-drug conjugates (ADCs).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	8-10 weeks	8-10 weeks
5 mg	$88	8-10 weeks	8-10 weeks
10 mg	$132	8-10 weeks	8-10 weeks
25 mg	$252	8-10 weeks	8-10 weeks
50 mg	$429	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Val-Ala-PABC-Exatecan is a drug-linker conjugate comprising the cleavable linker Tesirine and the topoisomerase I inhibitor Exatecan, used in synthesising antibody-drug conjugates (ADCs).

Chemical Properties

Molecular Weight	754.80
Formula	C₄₀H₄₃FN₆O₈
Cas No.	2845164-91-0
Smiles	N(C(OCC1=CC=C(NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)C=C1)=O)[C@@H]2C3=C4C(C=5N(C4)C(=O)C6=C(C5)[C@](CC)(O)C(=O)OC6)=NC=7C3=C(CC2)C(C)=C(F)C7

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (105.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3249 mL	6.6243 mL	13.2485 mL	66.2427 mL
5 mM	0.2650 mL	1.3249 mL	2.6497 mL	13.2485 mL
10 mM	0.1325 mL	0.6624 mL	1.3249 mL	6.6243 mL
20 mM	0.0662 mL	0.3312 mL	0.6624 mL	3.3121 mL
50 mM	0.0265 mL	0.1325 mL	0.2650 mL	1.3249 mL
100 mM	0.0132 mL	0.0662 mL	0.1325 mL	0.6624 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc