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12(S)-HpETE

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Catalog No. T37969Cas No. 71774-10-2

12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LOE. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.

12(S)-HpETE
Other Forms of 12(S)-HpETE:

12(S)-HpETE

😃Good
Catalog No. T37969Cas No. 71774-10-2
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LOE. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μg$47535 days35 days
50 μg$88835 days35 days
100 μg$1,68035 days35 days
250 μg$3,72035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Bioactivity
Description
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LOE. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.
Chemical Properties
Molecular Weight336.47
FormulaC20H32O4
Cas No.71774-10-2
Smiles[C@@H](/C=C/C=C\C/C=C\CCCC(O)=O)(C/C=C\CCCCC)OO
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
PBS (pH 7.2): < 1 mg/ml (slightly soluble or insoluble), Sonication is recommended.
0.1 M Na2CO3: 1 mg/mL (2.97 mM), Sonication is recommended.
Solution Preparation Table
0.1 M Na2CO3
1mg5mg10mg50mg
1 mM2.9720 mL14.8602 mL29.7203 mL148.6017 mL

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Keywords

12HpETE12(S)HpETE12(S) HpETE
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