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ATAC21

Name: ATAC21
Brand: TargetMol
SKU: T82954
Rating: 4.5 (1 reviews)

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Catalog No. T82954Cas No. 2101204-23-1

ATAC21 is a linker-immune-stimulatory compound created by conjugating a noncleavable maleimide-PEG4 linker, which includes a succinimide group, with an immune-stimulatory agent. This compound can be further conjugated with SBT-040 (anti-CD40 antibody) to form a conjugate [1].

ATAC21

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Catalog No. T82954Cas No. 2101204-23-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	8-10 weeks	8-10 weeks
50 mg	Inquiry	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

In vitro

A recombinant bispecific antibody comprises: a) a target antigen-binding domain that specifically binds to a tumor-associated antigen; b) an effector antigen-binding domain that specifically binds to an antigen on antigen-presenting cells, where the antigen is a molecule on the surface of antigen-presenting cells; c) an Fc-containing domain; and d) an immune-stimulatory compound linked to the recombinant bispecific antibody through a linker. This recombinant bispecific antibody, when bound to both the tumor-associated antigen and the antigen on antigen-presenting cells as opposed to only the latter, elicits greater immune cell activation. However, it does not target the tumor-associated antigen [1].

Chemical Properties

Molecular Weight	1072.82
Formula	C₃₈H₅₀N₁₂O₂₁P₂
Cas No.	2101204-23-1
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(NC(CCOCCOCCOCCOCCNC(CCN4C(=O)C=CC4=O)=O)=O)N=CN3)O[C@]5([C@]1(OP(=O)(O)OC[C@@]6([C@@](OP(=O)(O)OC5)([C@@H](O)[C@@H](O6)N7C8=C(N=C7)C(=O)N=C(N)N8)[H])[H])[H])[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc