ATAC21

Name: ATAC21
Brand: TargetMol
SKU: T82954
Rating: 4.5 (1 reviews)

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Catalog No. T82954Cas No. 2101204-23-1

ATAC21 is a linker-immune-stimulatory compound created by conjugating a noncleavable maleimide-PEG4 linker, which includes a succinimide group, with an immune-stimulatory agent. This compound can be further conjugated with SBT-040 (anti-CD40 antibody) to form a conjugate [1].

ATAC21

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Catalog No. T82954Cas No. 2101204-23-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	8-10 weeks	8-10 weeks
50 mg	Inquiry	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description

In vitro

A recombinant bispecific antibody comprises: a) a target antigen-binding domain that specifically binds to a tumor-associated antigen; b) an effector antigen-binding domain that specifically binds to an antigen on antigen-presenting cells, where the antigen is a molecule on the surface of antigen-presenting cells; c) an Fc-containing domain; and d) an immune-stimulatory compound linked to the recombinant bispecific antibody through a linker. This recombinant bispecific antibody, when bound to both the tumor-associated antigen and the antigen on antigen-presenting cells as opposed to only the latter, elicits greater immune cell activation. However, it does not target the tumor-associated antigen [1].

Chemical Properties

Molecular Weight	1072.82
Formula	C₃₈H₅₀N₁₂O₂₁P₂
Cas No.	2101204-23-1
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(NC(CCOCCOCCOCCOCCNC(CCN4C(=O)C=CC4=O)=O)=O)N=CN3)O[C@]5([C@]1(OP(=O)(O)OC[C@@]6([C@@](OP(=O)(O)OC5)([C@@H](O)[C@@H](O6)N7C8=C(N=C7)C(=O)N=C(N)N8)[H])[H])[H])[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc