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N,N'-Dinitrosopiperazine

Name: N,N'-Dinitrosopiperazine
Brand: TargetMol
SKU: T81720
Rating: 4.5 (1 reviews)

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Catalog No. T81720Cas No. 140-79-4

Alias DNPZ, 1,4-Dinitrosopiperazine

N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine, DNP) is a known carcinogen associated with the development and metastasis of nasopharyngeal carcinoma. Its carcinogenic mechanism involves multiple signaling pathways, particularly exerting effects through the regulation of phosphorylation at the Ser568 site of the LYRIC protein. It can be used to induce esophageal cancer models.

N,N'-Dinitrosopiperazine

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Catalog No. T81720Alias DNPZ, 1,4-DinitrosopiperazineCas No. 140-79-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	8-10 weeks	8-10 weeks
50 mg	Inquiry	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine, DNP) is a known carcinogen associated with the development and metastasis of nasopharyngeal carcinoma. Its carcinogenic mechanism involves multiple signaling pathways, particularly exerting effects through the regulation of phosphorylation at the Ser568 site of the LYRIC protein. It can be used to induce esophageal cancer models.
In vitro	N,N'-Dinitrosopiperazine (referred to herein as 0.) exhibits specific activity within chemical processes by engaging in reactions characteristic to its molecular structure.
In vivo	N,N'-Dinitrosopiperazine (administered via tail vein injection; 40 mg/kg; 30 days) suppresses cell motility and invasion while promoting nasopharyngeal carcinoma (NPC) metastasis in vivo. Immunohistochemistry (IHC) reveals that phospho-LYRIC levels are elevated in the metastatic tumors of DNP-treated mice compared to untreated controls [1].
Synonyms	DNPZ, 1,4-Dinitrosopiperazine

Chemical Properties

Molecular Weight	144.13
Formula	C₄H₈N₄O₂
Cas No.	140-79-4
Smiles	O=NN1CCN(N=O)CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3 mg/mL (20.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9382 mL	34.6909 mL	69.3818 mL	346.9090 mL
5 mM	1.3876 mL	6.9382 mL	13.8764 mL	69.3818 mL
10 mM	0.6938 mL	3.4691 mL	6.9382 mL	34.6909 mL
20 mM	0.3469 mL	1.7345 mL	3.4691 mL	17.3455 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc