Powder: -20°C for 3 years | In solvent: -80°C for 1 year
D-685, a prodrug of D-520, demonstrates enhanced anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model compared to its parent compound D-520. It effectively reduces the buildup of human α-synuclein (α-syn) protein and readily penetrates the brain [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | D-685, a prodrug of D-520, demonstrates enhanced anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model compared to its parent compound D-520. It effectively reduces the buildup of human α-synuclein (α-syn) protein and readily penetrates the brain [1]. |
In vivo | D-685 (12 mg/kg; intraperitoneal injection daily; for one month) reduced the accumulation of α-synuclein in transgenic mice [1]. When compared to the use of Lisuride alone, D-685 (10 μmol/kg; intraperitoneal injection) was highly effective in reversing motor deficits in Sprague-Dawley rats (male and female, weighing 220-225 g) and notably enhanced locomotor activity over a 6-hour study period [1]. D-685 demonstrated a high brain-to-plasma ratio (B/P: 4) which suggests easy penetration into the brain following intraperitoneal administration [1]. |
Molecular Weight | 513.67 |
Formula | C32H39N3O3 |
CAS No. | 2893801-00-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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D-685 2893801-00-6 inhibitor inhibit