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85548e

Catalog No. T24989 CAS 124020-62-8

Synonyms: 85548 e, 85548-e, U 85548e, U85548e, U-85548e

85548e is used as an inhibitor that exhibiting subnanomolar affinity towards HIV type-1 aspartic proteinase (HIV-1 PR).

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85548e, CAS 124020-62-8

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

85548e is used as an inhibitor that exhibiting subnanomolar affinity towards HIV type-1 aspartic proteinase (HIV-1 PR).

Synonyms	85548 e, 85548-e, U 85548e, U85548e, U-85548e
Molecular Weight	872.075
Formula	C40H73N9O12
CAS No.	124020-62-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Sawyer TK, Staples DJ, Liu L, Tomasselli AG, Hui JO, O'Connell K, Schostarez H, Hester JB, Moon J, Howe WJ, et al. HIV protease (HIV PR) inhibitor structure-activity-selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH2]Val modified viral and nonviral substrate analogs. Int J Pept Protein Res. 1992 Sep-Oct;40(3-4):274-81. PubMed PMID: 1478785. 2. Jaskólski M, Tomasselli AG, Sawyer TK, Staples DG, Heinrikson RL, Schneider J, Kent SB, Wlodawer A. Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor. Biochemistry. 1991 Feb 12;30(6):1600-9. PubMed PMID: 1993177. 3. Obrzut SL, Koren AO, Mandelkern MA, Brody AL, Hoh CK, London ED. Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studies. Nucl Med Biol. 2005 Nov;32(8):869-74. PubMed PMID: 16253812. 4. Swain AL, Gustchina A, Wlodawer A. Comparison of three inhibitor complexes of human immunodeficiency virus protease. Adv Exp Med Biol. 1991;306:433-41. PubMed PMID: 1812740.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

85548e 124020-62-8 85548 e 85548-e U 85548e U85548e U-85548e inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.