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BRD0639

Name: BRD0639
Brand: TargetMol
SKU: T9329
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9329Cas No. 2760881-74-9

BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM), BRD0639 facilitates the investigation of activities dependent on PBM-associated PRMT5 functions [1].

BRD0639

🥰Excellent

Purity: 99.85%

Catalog No. T9329Cas No. 2760881-74-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$413	In Stock	In Stock
50 mg	$563	In Stock	In Stock
100 mg	$788	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vitro

BRD0639, a pioneering PBM-competitive small molecule, facilitates the research of PBM-dependent PRMT5 activities and aids in developing specific PRMT5 inhibitors. It effectively binds to the cellular target, efficiently inhibiting the interaction between full-length PRMT5 and RIOK1 proteins with IC50 values of 7.5 uM and 16 uM in permeabilized and living cells, respectively. Moreover, BRD0639 decreases SDMA levels in proteins impacted by genetic alterations of the PRMT5 binding motif (PBM) site [1].

Chemical Properties

Molecular Weight	475.95
Formula	C₂₁H₂₂ClN₅O₄S
Cas No.	2760881-74-9
Smiles	S(NCCC1=CC=CC=N1)(=O)(=O)C2=CC(NC([C@H](C)N3C(=O)C=C(Cl)C=N3)=O)=CC=C2C
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (126.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1011 mL	10.5053 mL	21.0106 mL	105.0531 mL
5 mM	0.4202 mL	2.1011 mL	4.2021 mL	21.0106 mL
10 mM	0.2101 mL	1.0505 mL	2.1011 mL	10.5053 mL
20 mM	0.1051 mL	0.5253 mL	1.0505 mL	5.2527 mL
50 mM	0.0420 mL	0.2101 mL	0.4202 mL	2.1011 mL
100 mM	0.0210 mL	0.1051 mL	0.2101 mL	1.0505 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc