Carbon-13 Labeled Compounds

L-Lysine-13C6-15N2 Hydrochloride is L-Lysine hydrochloride labeled with 13C and 15N isotopes. L-Lysine hydrochloride is an essential amino acid for humans and a common food additive. It stimulates the secretion of pepsin and gastric acid, enhances gastric juice secretion, and promotes growth and development in children.

Phenol-13C6 is a 13C-labeled Phenol, which is an important chemical raw material used in the manufacture of fungicides and herbicides.

D-Fructose-13C6 can be used as an internal standard for the quantification of D-fructose by GC- or LC-MS.

L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.

Vancomycin-C13,D3 is a compound labeled with 13C and 2H. Vancomycin is a glycopeptide antibiotic that exerts antibacterial activity by altering cell membrane permeability and selectively inhibiting RNA synthesis.

Apalutamide-13C-d3 (RN-509-13C,d3) is a 13C and 2H-labeled version of Apalutamide. Apalutamide is an efficient androgen receptor (AR) antagonist used in the study of prostate diseases.

Riluzole-13C,15N2 (PK 26124-13C,15N2) is a 13C and 15N labeled form of Riluzole. Riluzole is a glutamate antagonist with anticonvulsant activity, inhibiting GABA reuptake and used in ALS research.

Binimetinib-13C-d3 (MEK162-13C-d3) is an isotopically labelled compound of Binimetinib for use as a tracer.Binimetinib (ARRY-162) is a selective MEK1/2 inhibitor for the treatment of melanoma.

Apixaban 13C,d3 is a deuterium labeling of Apixaban for isotopic tracing. Apixaban 13C,d3 is a selective inhibitor of coagulation factor Xa and is used in thromboembolism studies

Cyanuric acid-13C3 is a 13C-labelled compound of cyanuric acid, which can be used for isotope tracing. Cyanuric acid is a triazine compound, fungicide, and herbicide.

4-Trifluoromethylsalicylic acid-13C6 is 13C-labeled 4-Trifluoromethylsalicylic acid, mainly used as a quantitative tracer in drug development. 4-Trifluoromethylsalicylic acid is also a platelet aggregation inhibitor.

2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis.

1,2-Dioleoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2-dioleoyl-rac-glycerol by GC- or LC-MS. 1,2-dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at the sn-1 and sn-2 positions. It effectively binds the C1 domain to activate conventional protein kinase C forms and serves as a substrate for diacylglycerol kinases and multisubstrate lipid kinase.1,2,3 |1. Yamaguchi, Y., Shirai, Y., Matsubara, T., et al. Phosphorylation and up-regulation of diacylglycerol kinase γ via its interaction with protein kinase Cγ. J. Biol. Chem. 281(42), 31627-31637 (2006).|2. Zhou, Q.Z., Raynor, R.L., Wood, M.G., Jr., et al. Structure-activity relationship of synthetic branched-chain distearoylglycerol (distearin) as protein kinase C activators. Biochemistry 27(19), 7361-7365 (1988).|3. Epand, R.M., Shulga, Y.V., Timmons, H.C., et al. Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase. Biochemistry 46(49), 14225-14231 (2007).

2,4-Dichlorophenol-13C6 the 13C and deuterated compound of 2,4-Dichlorophenol. 2,4-Dichlorophenol has a CAS number of 120-83-2. 2,4-Dichlorophenol is the precursor to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D).

trans-Hydroxy Loxoprofen-13C-d3 (Mixture of Diastereomers) the 13C and deuterated compound of trans-Hydroxy Loxoprofen. trans-Hydroxy Loxoprofen has a CAS number of 371753-19-4.

Ethyl Acetate-13C2 is the 13C labeled compound of Ethyl Acetate. Ethyl Acetate has a CAS number of 141-78-6.

Nicergoline-13C-d3 the 13C and deuterated compound of Nicergoline. Nicergoline has a CAS number of 27848-84-6. Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins.

Lercanidipine-13C-d3 HCl the 13C and deuterated compound of Lercanidipine HCl. Lercanidipine HCl has a CAS number of 132866-11-6. Lercanidipine is a calcium channel blocker of the dihydropyridine class.

Ondansetron-13C-d3 the 13C and deuterated compound of Ondansetron. Ondansetron has a CAS number of 99614-02-5. Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.

13C-d3-AOH1996 is the 13C and deuterated compound of AOH1996. 13C-AOH1996 has a CAS number of 2089314-64-5. AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis.AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II.AOH1996 acts synergistically with DNA damaging agents to inhibit tumor cell growth. AOH1996 inhibits tumor cell growth by stabilizing the interaction between PCNA and RNA polymerase II, leading to proteasome-dependent rpb1 degradation and lethal DNA damage.AOH1996 acts synergistically with DNA damaging agents.

Vadadustat-13C2-15N is 13C and 15N labeled Vadadustat. Vadadustat has a CAS number of 1000025-07-9. Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

Sofosbuvir-13C-d3 is the 13C and deuterated compound of Sofosbuvir. Sofosbuvir has a CAS number of 1190307-88-0. Sofosbuvir is a uridine monophosphate analog inhibitor of hepatitis C virus (HCV) polymerase NS5B that is used as an antiviral agent in the treatment of chronic hepatitis C.

Taltirelin-13C-d3 is the 13C and deuterated compound of Taltirelin. Taltirelin has a CAS number of 103300-74-9. Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].

Roxadustat-13C-15N is 13C and 15N labeled Roxadustat.