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Claudin-18.2 Protein, Human, Recombinant (Twin strep & Flag)
(Synonyms: CLDN18.2, CLDN18, Claudin-18.2, Claudin-18, Claudin 18.2) Copy Product InfoSynonyms: CLDN18.2, CLDN18, Claudin-18.2, Claudin-18, Claudin 18.2
Catalog No. TMPJ-01028 Copy Product Info
Claudin-18 (CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. Human CLDN18.2 is highly expressed in a signifcant proportion of gastric and pancreatic adenocarcinomas，while normal tissue expression is limited to the epithelium of the stomach. The restricted expression makes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, as evidenced by eforts to target CLDN18.2 via naked antibody and CAR-T modalities. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $465 | 7-10 days | 7-10 days | |
| 20 µg | $746 | 7-10 days | 7-10 days | |
| 50 µg | $1,400 | 7-10 days | 7-10 days | |
| 100 µg | $2,280 | 7-10 days | 7-10 days | |
| 200 µg | $3,790 | 7-10 days | 7-10 days | |
| 500 µg | $7,400 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1. Loaded Anti-Human Claudin 18.2 mAb-Fc on AHC Biosensor, can bind Human Claudin-18.2-Flag with an affinity constant of 6.76 nM as determined in BLI assay. (Regularly tested)
2. Immobilized Recombinant Human Claudin-18.2-Flag at 5μg/ml (100 μl/well) can bind Anti-Human Claudin 18.2 mAb-Fc. The ED50 of Anti-Human Claudin 18.2 mAb-Fc is 1.54 ng/ml. (Regularly tested) |
| Description | Claudin-18 (CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. Human CLDN18.2 is highly expressed in a signifcant proportion of gastric and pancreatic adenocarcinomas，while normal tissue expression is limited to the epithelium of the stomach. The restricted expression makes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, as evidenced by eforts to target CLDN18.2 via naked antibody and CAR-T modalities. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-Twin strep-Flag |
| Accession Number | P56856-2 |
| Amino Acid | Met1-Ala200 |
| Construction | Met1-Ala200 |
| Protein Purity | Greater than 70% as determined by reducing SDS-PAGE. Greater than 70% as determined by SEC-HPLC. |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, 0.06% DDM, 0.012% CHS, 10% Glycerol, pH 7.5. |
| Synonyms | CLDN18.2, CLDN18, Claudin-18.2, Claudin-18, Claudin 18.2 |
| Research Background | Claudin-18 (CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. Human CLDN18.2 is highly expressed in a signifcant proportion of gastric and pancreatic adenocarcinomas，while normal tissue expression is limited to the epithelium of the stomach. The restricted expression makes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, as evidenced by eforts to target CLDN18.2 via naked antibody and CAR-T modalities. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG. |
| Molecular Weight | 18-22 kDa (reducing condition) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Claudin-18.2 Protein, Human, Recombinant (Twin strep & Flag) chemical structure | Claudin-18.2 Protein, Human, Recombinant (Twin strep & Flag) molecular weight
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