Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cells. In the presence of endogenous copper in tumor tissues, SA-PA undergoes in situ conversion to active PROTAC through a click reaction [1].
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Description | SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cells. In the presence of endogenous copper in tumor tissues, SA-PA undergoes in situ conversion to active PROTAC through a click reaction [1]. |
Molecular Weight | 873.19 |
Formula | C40H32ClF3N10O8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SA-PA PROTAC PROTACs inhibitor inhibit