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PROTAC Selection

FilterHomePROTACPROTAC Selection
  • ARV-771
    T54351949837-12-0
    Glycodeoxycholic Acid is an endogenous metabolite, a natural product found in Streptomyces niger, Trypanosoma brucei, and Cryptomonas, which induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.
    • $55
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  • tri-GalNAc-COOH
    T393701953146-81-0In house
    Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
    • $255
    In Stock
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    TargetMol | Inhibitor Hot
  • cis VH 032, amine dihydrochloride
    T354782376990-32-6
    cis VH 032, amine dihydrochloride ((S,S,S)-AHPC) is a negative control for the functionalized VHL ligand VH 032, amine .
    • $51
    In Stock
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  • β-NF-JQ1
    T105262380000-55-3In house
    β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein interactions. β-NF-JQ1 shows potent anticancer activity associated with protein knockdown activity. .
    • $97
    In Stock
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  • BETd-260
    T145502093388-62-4In house
    BETd-260, a PROTAC linked by a Cereblon ligand and a BET ligand, has an inhibitory effect on BRD4 protein in leukemic cell lines.
    • $212
    In Stock
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  • FKBP12 PROTAC dTAG-7
    T112922064175-32-0In house
    FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
    • $1,280
    35 days
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  • VH032
    T291061448188-62-2In house
    VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a ligand of VHL.
    • $44
    In Stock
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  • dMCL1-2
    T136572351218-88-5In house
    dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apoptosis mechanism by degrading MCL1.This compound is unstable in powder form and other related salt forms are recommended.
    • $3,200
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  • Fmoc-PEA
    T17977329223-23-6In house
    Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).
    • $43
    In Stock
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  • QCA570
    T167012207569-08-0In house
    QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).
    • Inquiry Price
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  • dBET6
    T51301950634-92-0
    dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
    • $48
    In Stock
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    TargetMol | Citations Cited
  • PROTAC BET Degrader-1
    T138492093386-22-0
    PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
    • $456
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  • MZP-54
    T137852010159-47-2
    MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
    • $456
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  • BETd-246
    T145492140289-17-2
    BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.
    • $539
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  • PROTAC FLT-3 degrader 1
    T125552230826-81-8
    PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.
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  • PROTAC EED degrader-2
    T12554
    PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
    • Inquiry Price
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  • ZXH-3-26
    T172972243076-67-5
    ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
    • $320
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  • PROTAC BRD4 Degrader-1
    T138332133360-00-4
    PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
    • Inquiry Price
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  • INY-03-041
    T11664
    INY-03-041, a potent and highly selective PROTAC-based pan-AKT degrader, inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. This compound consists of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide.
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  • TL13-112
    T139292229037-19-6
    TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
    • $1,080
    35 days
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  • MS4077
    T137812230077-10-6
    MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
    • $871
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  • SJFα
    T186812254609-27-1
    SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 μM[1].
    • $735
    35 days
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  • (S,R,S)-AHPC-PEG6-C4-Cl
    T179261835705-59-3
    (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
    • $61
    5 days
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  • JH-XI-10-02
    T137432209085-22-1
    JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.
    • $1,440
    35 days
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  • CP5V
    T108752509359-75-3
    CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation.
    • $393
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  • ERD-308
    T136852320561-35-9
    ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).ERD-308 is a highly potent PROTAC degrade
    • $913
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  • PROTAC Sirt2 Degrader-1
    T166672098487-75-1
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
    • Inquiry Price
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  • VZ185
    T172492306193-61-1
    VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
    • $735
    35 days
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  • PROTAC RIPK degrader-2
    T138461801547-16-9
    PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
    • Inquiry Price
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  • (S,R,S)-AHPC-C6-PEG3-C4-Cl
    T179111835705-55-9
    (S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
    • $61
    5 days
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    TargetMol | Inhibitor Sale
  • FKBP12 PROTAC dTAG-13
    T112912064175-41-1
    FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.
    • $1,350
    35 days
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    TargetMol | Inhibitor Sale
  • PROTAC BET degrader-2
    T125592093388-33-9
    PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
    • $398
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  • PROTAC Mcl1 degrader-1
    T119752163793-38-0
    PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
    • $456
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  • PROTAC FAK degrader 1
    T138402301916-69-6
    PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
    • $456
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  • TL13-12
    T139302229037-04-9
    TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
    • $1,070
    35 days
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  • GNE-987
    T114412417371-71-0
    GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and 4.4 nM, respectively). GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50: 0.03
    • $494
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  • KB02-SLF
    T18061
    KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of protein degradation in biological systems. The compound SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, resulting in the formation of KB02-SLF[1].
    • Inquiry Price
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  • PROTAC BRD9 Degrader-1
    T125602097971-01-0
    PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
    • $733
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  • CP-10
    T136272366268-80-4
    CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
    • $728
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  • Homo-PROTAC cereblon degrader 1
    T137212244520-98-5
    Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
    • $228
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  • PROTAC PARP1 degrader
    T138452369022-68-2
    PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM).
    • Inquiry Price
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  • ARCC-4
    T143181973403-00-7
    ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1].
    • $1,080
    35 days
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  • PROTAC K-Ras Degrader-1
    T138442378258-52-5
    PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
    • $456
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  • MG-277
    T12027
    MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
    • Inquiry Price
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  • MT-802
    T161572231744-29-7
    MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).
    • $147
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  • (S,R,S)-AHPC-PEG2-C4-Cl
    T179101835705-57-1
    (S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
    • $61
    5 days
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    QTY
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  • PROTAC EED degrader-1
    T12553
    PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
    • Inquiry Price
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  • MZP-55
    T137862010159-48-3
    MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
    • $456
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  • SIAIS178
    T129072376047-73-1
    SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).
    • $166
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  • BRD4 degrader AT1
    T54392098836-45-2
    BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
    • $1,100
    35 days
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