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Trimethyl chitosan (Synonyms: N,N,N-Trimethylchitosan)
Catalog No. T84764 Copy Product Info
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Trimethyl chitosan is a cationic polymer derived from chemically modified natural chitosan; its water solubility and biocompatibility are enhanced through trimethylation of the amino groups. Trimethyl chitosan targets absorption-enhancing proteins in the tight junctions of intestinal and mucosal epithelial cells, thereby improving drug absorption and stability on mucosal surfaces. Trimethyl chitosan can stimulate the activity that promotes the transmembrane transport of hydrophilic drugs and can be used for drug delivery and the synthesis of nanoparticles.
Trimethyl chitosan
Copy Product Info🥰Excellent
Catalog No. T84764
Synonyms N,N,N-Trimethylchitosan
Trimethyl chitosan is a cationic polymer derived from chemically modified natural chitosan; its water solubility and biocompatibility are enhanced through trimethylation of the amino groups. Trimethyl chitosan targets absorption-enhancing proteins in the tight junctions of intestinal and mucosal epithelial cells, thereby improving drug absorption and stability on mucosal surfaces. Trimethyl chitosan can stimulate the activity that promotes the transmembrane transport of hydrophilic drugs and can be used for drug delivery and the synthesis of nanoparticles.
Cas No. 52349-26-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | $30 | - | In Stock | |
| 25 mg | $45 | - | In Stock | |
| 50 mg | $64 | - | In Stock | |
| 100 mg | $103 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Trimethyl chitosan is a cationic polymer derived from chemically modified natural chitosan; its water solubility and biocompatibility are enhanced through trimethylation of the amino groups. Trimethyl chitosan targets absorption-enhancing proteins in the tight junctions of intestinal and mucosal epithelial cells, thereby improving drug absorption and stability on mucosal surfaces. Trimethyl chitosan can stimulate the activity that promotes the transmembrane transport of hydrophilic drugs and can be used for drug delivery and the synthesis of nanoparticles. |
| In vitro | The addition of Trimethyl chitosan (0.05–1.0% (w/v); 2–4 h) to Caco-2 monolayers resulted in a concentration-dependent decrease in transepithelial electrical resistance (TEER) and a significant increase in the transmembrane transport efficiency of 14C-mannitol, with no significant effect on cell viability. [1] |
| Synonyms | N,N,N-Trimethylchitosan |
| Cas No. | 52349-26-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | H2O: 26.66 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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