keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IR-251 is a mitochondrion-targeting near-infrared (NIR) fluorescent probe that selectively accumulates in tumor cell mitochondria through organic anion transporting polypeptides (OATPs), leading to mitochondrial dysfunction. By impeding peroxisome proliferator-activated receptor gamma (PPARγ), IR-251 promotes reactive oxygen species (ROS) overproduction, consequently inhibiting the β-catenin signaling pathway as well as associated cell cycle and metastasis proteins. This mechanism contributes to the compound's ability to suppress tumor growth and metastasis [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | IR-251 is a mitochondrion-targeting near-infrared (NIR) fluorescent probe that selectively accumulates in tumor cell mitochondria through organic anion transporting polypeptides (OATPs), leading to mitochondrial dysfunction. By impeding peroxisome proliferator-activated receptor gamma (PPARγ), IR-251 promotes reactive oxygen species (ROS) overproduction, consequently inhibiting the β-catenin signaling pathway as well as associated cell cycle and metastasis proteins. This mechanism contributes to the compound's ability to suppress tumor growth and metastasis [1]. |
Molecular Weight | 886.48 |
Formula | C51H70BrClN4O2 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.