Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K i s of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 hydrochloride has antinociceptive activity with reduced opioid-induced relevant adverse events[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 228.00 | |
25 mg | 6-8 weeks | $ 1,400.00 | |
50 mg | 6-8 weeks | $ 1,820.00 |
Description | EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K i s of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 hydrochloride has antinociceptive activity with reduced opioid-induced relevant adverse events[1]. |
In vivo | EST73502 hydrochloride administered orally (10-40 mg/kg) demonstrates a dose-dependent analgesic effect, achieving a peak reduction in pain of 64% with an Effective Concentration (EC 50) of 14 mg/kg in the paw pressure test on CD1 male mice [1]. Additionally, intraperitoneal injections of EST73502 hydrochloride (5 mg/kg; twice daily for 10 days) significantly mitigate mechanical allodynia caused by partial sciatic nerve ligation (PSNL) in these mice, showing a maximum efficacy of 56% [1]. This is observed in the same CD1 male mouse model using PSNL to simulate the condition [1]. |
Molecular Weight | 388.88 |
Formula | C19H27ClF2N2O2 |
CAS No. | 2535970-65-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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EST73502 hydrochloride 2535970-65-9 EST73502 Hydrochloride EST-73502 Hydrochloride EST 73502 Hydrochloride inhibitor inhibit