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Dargistotug
🥰Excellent
Catalog No. T82609Cas No. 2649362-29-6
Alias M-6223, M6223
Dargistotug (M-6223), a fully human IgG1 monoclonal antibody, specifically binds to TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory checkpoint receptor that plays a critical role in immune regulation. Dargistotug (M-6223) mitigates NK cell depletion, enhances cytokine secretion, modulates effector T cell activity, and increases regulatory T cell (Treg) function, thereby contributing to the broader immunosuppressive environment. Dargistotug (M-6223) has thus become an important agent in research focused on immune checkpoint inhibition.
Dargistotug
Dargistotug
🥰Excellent
Purity: 95%
Catalog No. T82609Alias M-6223, M6223Cas No. 2649362-29-6
Dargistotug (M-6223), a fully human IgG1 monoclonal antibody, specifically binds to TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory checkpoint receptor that plays a critical role in immune regulation. Dargistotug (M-6223) mitigates NK cell depletion, enhances cytokine secretion, modulates effector T cell activity, and increases regulatory T cell (Treg) function, thereby contributing to the broader immunosuppressive environment. Dargistotug (M-6223) has thus become an important agent in research focused on immune checkpoint inhibition.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | - | In Stock | |
| 5 mg | $578 | - | In Stock | |
| 10 mg | $953 | - | In Stock | |
| 25 mg | $1,390 | - | In Stock | |
| 50 mg | $1,880 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95%
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Dargistotug (M-6223), a fully human IgG1 monoclonal antibody, specifically binds to TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory checkpoint receptor that plays a critical role in immune regulation. Dargistotug (M-6223) mitigates NK cell depletion, enhances cytokine secretion, modulates effector T cell activity, and increases regulatory T cell (Treg) function, thereby contributing to the broader immunosuppressive environment. Dargistotug (M-6223) has thus become an important agent in research focused on immune checkpoint inhibition. |
| Synonyms | M-6223, M6223 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Host Species | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID |
| Cas No. | 2649362-29-6 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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