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Dargistotug
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Catalog No. T82609Cas No. 2649362-29-6
Alias M-6223, M6223
Dargistotug (M-6223), a fully human IgG1 monoclonal antibody, specifically binds to TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory checkpoint receptor that plays a critical role in immune regulation. Dargistotug (M-6223) mitigates NK cell depletion, enhances cytokine secretion, modulates effector T cell activity, and increases regulatory T cell (Treg) function, thereby contributing to the broader immunosuppressive environment. Dargistotug (M-6223) has thus become an important agent in research focused on immune checkpoint inhibition.
Dargistotug
Dargistotug
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Purity: 95%
Catalog No. T82609Alias M-6223, M6223Cas No. 2649362-29-6
Dargistotug (M-6223), a fully human IgG1 monoclonal antibody, specifically binds to TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory checkpoint receptor that plays a critical role in immune regulation. Dargistotug (M-6223) mitigates NK cell depletion, enhances cytokine secretion, modulates effector T cell activity, and increases regulatory T cell (Treg) function, thereby contributing to the broader immunosuppressive environment. Dargistotug (M-6223) has thus become an important agent in research focused on immune checkpoint inhibition.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | - | In Stock | |
| 5 mg | $578 | - | In Stock | |
| 10 mg | $953 | - | In Stock | |
| 25 mg | $1,390 | - | In Stock | |
| 50 mg | $1,880 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.5% (SDS-PAGE); 97.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Dargistotug (M-6223), a fully human IgG1 monoclonal antibody, specifically binds to TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory checkpoint receptor that plays a critical role in immune regulation. Dargistotug (M-6223) mitigates NK cell depletion, enhances cytokine secretion, modulates effector T cell activity, and increases regulatory T cell (Treg) function, thereby contributing to the broader immunosuppressive environment. Dargistotug (M-6223) has thus become an important agent in research focused on immune checkpoint inhibition. |
| Synonyms | M-6223, M6223 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TIGIT/VSIG9/VSTM3 |
| Molecular Weight | 144.70 kDa |
| Cas No. | 2649362-29-6 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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