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XMD-12

Name: XMD-12
Brand: TargetMol
SKU: T71169
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71169Cas No. 1234481-08-3

Alias XMD12, XMD 12

XMD-12 is a selective pan-Aurora Kinase inhibitor, with an IC50 of 5.6/18.4/24.6 nM for Aurora A/B/C, with anti-tumor activity, and can promote the apoptosis of cancer cells induced by paclitaxel.

XMD-12

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Purity: 99.94%

Catalog No. T71169Alias XMD12, XMD 12Cas No. 1234481-08-3

XMD-12 is a selective pan-Aurora Kinase inhibitor, with an IC50 of 5.6/18.4/24.6 nM for Aurora A/B/C, with anti-tumor activity, and can promote the apoptosis of cancer cells induced by paclitaxel.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$293	-	In Stock
5 mg	$722	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,520	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,500	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.94%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	XMD-12 is a selective pan-Aurora Kinase inhibitor, with an IC50 of 5.6/18.4/24.6 nM for Aurora A/B/C, with anti-tumor activity, and can promote the apoptosis of cancer cells induced by paclitaxel.
Targets&IC50	Aurora B:18.4 nM, Aurora A:5.6 nM, Aurora C:24.6 nM
Synonyms	XMD12, XMD 12

Chemical Properties

Molecular Weight	430.5
Formula	C₂₄H₂₆N₆O₂
Cas No.	1234481-08-3
Smiles	O=C1C=2C=CC=CC2N(C3=NC(=NC=C3N1C)NC4=CC=C(C=C4)N5CCC(O)CC5)C
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (185.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3229 mL	11.6144 mL	23.2288 mL	116.1440 mL
5 mM	0.4646 mL	2.3229 mL	4.6458 mL	23.2288 mL
10 mM	0.2323 mL	1.1614 mL	2.3229 mL	11.6144 mL
20 mM	0.1161 mL	0.5807 mL	1.1614 mL	5.8072 mL
50 mM	0.0465 mL	0.2323 mL	0.4646 mL	2.3229 mL
100 mM	0.0232 mL	0.1161 mL	0.2323 mL	1.1614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc