Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological cancers[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 373.00 | |
10 mg | Inquiry | $ 663.00 | |
25 mg | Inquiry | $ 1,320.00 | |
50 mg | Inquiry | $ 2,150.00 | |
100 mg | Inquiry | $ 3,230.00 | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 397.00 |
Description | Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological cancers[1]. |
In vitro | Syk-IN-4 is a potent inhibitor of hERG with an IC50 of 3.0 μM[1].Syk-IN-4 inhibits SUDHL-4 and T cell proliferation with GI50s of 0.24 and 2.6 μM, respectively[1]. |
In vivo | Syk-IN-4 demonstrates moderate oral bioavailability (60%) when administered orally (1 mg/kg) in male Hans Wistar rats[1], while showing high plasma clearance (151 mL/min/kg) and large volume of distribution (1.0 L/kg respectively) upon intravenous administration (0.5 mg/kg) in the same animal model[1]. |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (148.99 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
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