Syk-IN-4

Name: Syk-IN-4
Brand: TargetMol
SKU: T37077
Rating: 4.5 (1 reviews)

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Catalog No. T37077

Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, with an IC50 of 0.31 nM, targeting SYK, a potential therapeutic target for autoimmunity and hematological cancers[1].

Syk-IN-4

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Catalog No. T37077

Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, with an IC50 of 0.31 nM, targeting SYK, a potential therapeutic target for autoimmunity and hematological cancers[1].

Pack Size	Price	Availability
5 mg	$373	Backorder
10 mg	$663	Backorder
25 mg	$1,320	Backorder
50 mg	$2,150	Backorder
100 mg	$3,230	Backorder
1 mL x 10 mM (in DMSO)	$397	Backorder

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Product Introduction

Bioactivity

Description	Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, with an IC50 of 0.31 nM, targeting SYK, a potential therapeutic target for autoimmunity and hematological cancers[1].
In vitro	Syk-IN-4 is a potent inhibitor of hERG with an IC50 of 3.0 μM[1], and it inhibits SUDHL-4 and T cell proliferation with GI50s of 0.24 μM and 2.6 μM, respectively[1].
In vivo	Syk-IN-4 demonstrates moderate oral bioavailability (60%) when administered orally (1 mg/kg) in male Hans Wistar rats[1], while showing high plasma clearance (151 mL/min/kg) and large volume of distribution (1.0 L/kg respectively) upon intravenous administration (0.5 mg/kg) in the same animal model[1].

Chemical Properties

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: 62.5 mg/mL (148.99 mM), Sonication is recommended.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc