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Ras

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.

  • BI-2865
    T720622937327-93-8
    BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants with an average IC50 value of approximately 140 nM.
    • $228
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  • Y16
    T3553429653-73-6
    Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions.
    • $30
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  • Adagrasib
    T83692326521-71-3
    Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.
    • $59
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  • MRTX1133
    T93032621928-55-8In house
    MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.
    • $197
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  • Sotorasib
    T86842296729-00-3
    Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.
    • $31
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  • BI-2493
    T720612937344-16-4In house
    BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
    • $630
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  • Rhosin hydrochloride
    T167451281870-42-5
    Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin h
    • $162
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  • RMC-6236
    T746982765081-21-6
    RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
    • $297
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  • (S)-(-)-Perillyl alcohol
    T828218457-55-1
    (S)-(-)-Perillyl alcohol (Perillyl alcohol) is a monoterpene extracted from Chamaecyparis obtusa with anticancer and neuroprotective activities.It inhibits farnesylation of Ras, up-regulates mannose 6-phosphate receptors and induces apoptosis.
    • $31
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  • Deltarasin
    T64621440898-61-2In house
    Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
    • $38
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  • SCH54292
    T9198188480-51-5
    SCH-54292 is a GDP exchange inhibitor.
    • $133
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  • RMC-7977
    T812632765082-12-8
    RMC-7977 is a highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with anticancer activity for the study of solid tumors with KRAS G12C mutations.
    • $263
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  • Ras Inhibitory Peptide acetate
    T37422L
    Ras Inhibitory Peptide acetate is a peptide involved in the Ras-dependent signaling pathway that plays an important role in human cancers initiated by oncogenic receptors.
    • $195
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  • Compound 3344 hydrochloride
    T9184L
    Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
    • $146
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  • 1-(4-methansulfinylphenyl)ethanone
    T887032361-73-2
    The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.
    • $78
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  • AZD4747
    T792132489226-14-2
    AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma.
    • $266
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  • (R)-BI-2852
    T720842375482-49-6In house
    (R)-BI-2852 can be used as (R)-5-isoindolin-1-one is used as an inhibitor of the RAS family of proteins and as a compound for the treatment and prevention of tumours. (R)-BI-2852 has Antiproliferative and antitumour agent activity.
    • $142
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  • CCG-257081
    T307781922098-90-5In house
    CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models. CCG-257081 can be used in cancer prevention and fibrosis research.
    • $129
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  • Digeranyl bisphosphonate
    T12452878143-03-4In house
    Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bisphosphonate induces autophagy but not apoptosis.
    • $263 TargetMol
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  • KRas G12C inhibitor 1
    T117762158297-28-8In house
    KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
    • $1,670
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  • XRP44X
    T20759729605-21-4In house
    XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
    • $50
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  • BI-2852
    T105332375482-51-0In house
    BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
    • $118
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  • KRAS G12C inhibitor 16
    T117702349392-79-4In house
    KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor with potential anticancer and antitumor activity, inhibits cancer cell proliferation, and can be used in the study of lung cancer.
    • $457
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  • Lonafarnib
    T6302193275-84-2
    Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
    • $41
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  • ML-210
    T83751360705-96-9
    ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
    • $34
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  • CCG-1423
    T2014285986-88-1
    CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
    • $32
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  • Kobe0065
    T1876436133-68-5
    Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
    • $39
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  • NSC 23766 trihydrochloride
    T63421177865-17-6
    NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
    • $52
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  • ML141
    T246371203-35-5
    ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).
    • $33
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  • Ketoconazole
    T067965277-42-1
    Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
    • $33
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  • EHop-016
    T24271380432-32-5
    EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.
    • $40
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  • RBC8
    T6634361185-42-4
    RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
    • $45
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  • GGTI298 Trifluoroacetate
    T68441217457-86-7
    GGTI298 Trifluoroacetate (GGTI 298 TFA salt) is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
    • $79
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  • ML-098
    T4619878978-76-8
    ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).
    • $33
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  • EHT 1864
    T6483754240-09-0
    EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
    • $39
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  • BI-3406
    T129792230836-55-0
    BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
    • $67
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  • FTI-277 hydrochloride
    T2700180977-34-8
    FTI-277 hydrochloride (FTI 277 HCl) is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I.
    • $48
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  • RMC-6291
    T751312641998-63-0
    RMC-6291 is an orally available, highly potent KRASG12C(ON) inhibitor with anticancer and antitumor activity that acts through spatial blockade of RAS effector binding.RMC-6291 blocks ERK signaling and induces apoptosis in KRASG12C-mutant H358 cells.
    • $162
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  • ADT-007
    T853161945941-09-2
    ADT-007 is an orally active and selective pan-RAS inhibitor with potent anticancer activity.ADT-007 blocks GTP activation of RAS and MAPK/AKT signaling by binding to anucleotide RAS.ADT-007 is used in the study of gastrointestinal cancers.
    • $42
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  • ARS-1630
    T103761698055-86-5
    ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.
    • $84
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  • 1588-A4
    T222491698027-20-1
    1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
    • $126
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  • K-Ras-IN-1
    T546984783-01-7
    K-Ras-IN-1 is a K-Ras inhibitor.
    • $45
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  • MC 976
    T16023129831-99-8
    MC 976 is a derivative of Vitamin D3.
    • $1,101
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  • HJC0197
    T154851383539-73-8
    HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).
    • $38
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  • RMC-4998
    T798702642037-07-6
    RMC-4998 is a molecular glue compound exhibiting potent antitumor activity, capable of forming a ternary complex with CYPA and an activated KRAS G12C mutation. Binding of CYPA to KRAS G12C impedes the interaction between activated KRAS mutants and downstream effector proteins, thus obstructing proliferative cell signaling [1].
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  • Kras4B G12D-IN-1
    T781702042365-85-3
    Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mutation[1].
    • $89
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  • pan-KRAS-IN-2
    T798002882825-14-9
    Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 >10 μM, for the KRAS G13D mutant [1].
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  • PROTAC K-Ras Degrader-1
    T138442378258-52-5
    PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
    • $456
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  • (S)-BAY-293
    T412142244904-69-4
    (S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.
    • $695
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  • K-Ras G12C-IN-4
    T117382376328-55-9
    K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..
    • $117
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