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Ras proteins are a class of small GTPases that serve as core regulatory factors within intracellular signalling networks. By switching between GDP and GTP states on the cell membrane, they modulate downstream pathways including MAPK/ERK and PI3K/AKT signalling, thereby influencing cellular proliferation, differentiation, and survival. In human tumours, mutations in Ras genes (KRAS, HRAS, NRAS) are extremely common, particularly KRAS, which is widely found in pancreatic, colorectal and lung cancers. These mutations typically result in Ras being perpetually activated, driving abnormal signalling and tumourigenesis.
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