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Bisindolylmaleimide III

Name: Bisindolylmaleimide III
Brand: TargetMol
SKU: T77628
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77628Cas No. 137592-43-9

Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC), specifically interacting with PKCα or ribosomal S6 protein kinase 1 upon activation of these kinases.

Bisindolylmaleimide III

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Purity: 98.6%

Catalog No. T77628Cas No. 137592-43-9

Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC), specifically interacting with PKCα or ribosomal S6 protein kinase 1 upon activation of these kinases.

Pack Size	Price	Availability
5 mg	$71	In Stock
10 mg	$116	In Stock
25 mg	$195	In Stock
50 mg	$289	In Stock
100 mg	$429	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock

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Batch Information

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Purity:98.6%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC), specifically interacting with PKCα or ribosomal S6 protein kinase 1 upon activation of these kinases.

Chemical Properties

Molecular Weight	384.43
Formula	C₂₃H₂₀N₄O₂
Cas No.	137592-43-9
Smiles	O=C1C(=C(C(=O)N1)C=2C=3C(NC2)=CC=CC3)C=4C=5C(N(CCCN)C4)=CC=CC5
Color	Red
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (117.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6013 mL	13.0063 mL	26.0125 mL	130.0627 mL
5 mM	0.5203 mL	2.6013 mL	5.2025 mL	26.0125 mL
10 mM	0.2601 mL	1.3006 mL	2.6013 mL	13.0063 mL
20 mM	0.1301 mL	0.6503 mL	1.3006 mL	6.5031 mL
50 mM	0.0520 mL	0.2601 mL	0.5203 mL	2.6013 mL
100 mM	0.0260 mL	0.1301 mL	0.2601 mL	1.3006 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc