GPRC5D Protein-VLP, Human, Recombinant

Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells.

Pack Size	Availability	Price/USD
20 μg	5 days	$ 838.00
100 μg	5 days	$ 1,670.00
500 μg	5 days	$ 5,310.00

Pack Size

Availability

Price/USD

Quantity

20 μg

5 days

$ 838.00

100 μg

5 days

$ 1,670.00

500 μg

5 days

$ 5,310.00

Description

Species	Human
Expression System	HEK293
Tag	Tag Free
Accession Number	Q9NZD1-1
Synonyms	GPRC5D
Construction	A DNA sequence encoding the human GPRC5D (Q9NZD1-1) (Met1-Val345) was expressed.
Molecular Weight	38.80 kDa (predicted)

Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Formulation	Supplied as sterile solution in 50mM HEPES, 150mM NaCI, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	It is supplied and shipped as Solution with dry ice.
Research Background	Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells.