9-cis-β-Carotene

Name: 9-cis-β-Carotene
Brand: TargetMol
SKU: T13524
Rating: 4.5 (1 reviews)

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Catalog No. T13524Cas No. 13312-52-2

9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal, which inhibits photoreceptor degeneration and restores retinal function in vivo.

9-cis-β-Carotene

😃Good

Catalog No. T13524Cas No. 13312-52-2

9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal, which inhibits photoreceptor degeneration and restores retinal function in vivo.

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Product Introduction

Bioactivity

Description	9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal, which inhibits photoreceptor degeneration and restores retinal function in vivo.
In vitro	9-cis-β-Carotene (1 μM; 18 hours), combined with Miglyol 810 and an antioxidant mix, is applied to eye cups derived from RPE65rd12 mice with the neuro-retina still attached to the underlying RPE tissue. This treatment significantly prevents degeneration of S- and M-cones, resulting in more than a 2- and 9-fold increase in m-opsin and s-opsin positive staining, respectively, compared to the control group.
In vivo	In a mouse model exhibiting defects in the retinoid cycle, specifically the RPE65rd12 mutation, administration of an extract from Dunaliella Bardawil algae, which is rich in 9-cis-β-Carotene (9CBC), via oral route, has been shown to rescue retinal function and preserve cone structure.

Chemical Properties

Molecular Weight	536.87
Formula	C₄₀H₅₆
Cas No.	13312-52-2
Smiles	C(=C/C(=C\C=C\C(=C\C=C\C=C(\C=C\C=C(\C=C\C=1C(C)(C)CCCC1C)/C)/C)\C)/C)\C=2C(C)(C)CCCC2C
Relative Density.	0.941 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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