Dihydro-5-azacytidine acetate

Name: Dihydro-5-azacytidine acetate
Brand: TargetMol
SKU: T78565
Rating: 4.5 (1 reviews)

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Catalog No. T78565Cas No. 2470972-18-8

Alias NSC 264880 acetate, DHAC acetate

Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2].

Dihydro-5-azacytidine acetate

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Catalog No. T78565Alias NSC 264880 acetate, DHAC acetateCas No. 2470972-18-8

Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2].

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2].
In vitro	Methylation analysis reveals a [3H]DHAC LD 10 exposure leads to 25.06% DNA hypomethylation in L1210/0 cells and 46.32% in L1210/dCK(-) deoxycytidine kinase mutant cells relative to controls [2]. Furthermore, dihydro-5-azacytidine (DHAC) vies with cytidine triphosphate for RNA integration, culminating in ribosomal breakdown and impaired protein synthesis [1].
In vivo	In a murine model bearing L1210/0-induced tumors, administration of an LD 10 of Dihydro-5-azacytidine (DHAC; 1500 mg/kg) results in a peak plasma concentration of 317 μM. The compound is biexponentially eliminated, with a first-phase half-life (t 1/2 α) of 1.03 hours and a second-phase half-life (t 1/2 β) of 5 hours [2].
Synonyms	NSC 264880 acetate, DHAC acetate

Chemical Properties

Molecular Weight	306.27
Formula	C₁₀H₁₈N₄O₇
Cas No.	2470972-18-8

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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