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Dihydro-5-azacytidine acetate

Name: Dihydro-5-azacytidine acetate
Brand: TargetMol
SKU: T78565
Rating: 4.5 (1 reviews)

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Catalog No. T78565Cas No. 2470972-18-8

Alias NSC 264880 acetate, DHAC acetate

Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2].

Dihydro-5-azacytidine acetate

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Catalog No. T78565Alias NSC 264880 acetate, DHAC acetateCas No. 2470972-18-8

Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2].

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2].
In vitro	Methylation analysis reveals a [3H]DHAC LD 10 exposure leads to 25.06% DNA hypomethylation in L1210/0 cells and 46.32% in L1210/dCK(-) deoxycytidine kinase mutant cells relative to controls [2]. Furthermore, dihydro-5-azacytidine (DHAC) vies with cytidine triphosphate for RNA integration, culminating in ribosomal breakdown and impaired protein synthesis [1].
In vivo	In a murine model bearing L1210/0-induced tumors, administration of an LD 10 of Dihydro-5-azacytidine (DHAC; 1500 mg/kg) results in a peak plasma concentration of 317 μM. The compound is biexponentially eliminated, with a first-phase half-life (t 1/2 α) of 1.03 hours and a second-phase half-life (t 1/2 β) of 5 hours [2].
Synonyms	NSC 264880 acetate, DHAC acetate

Chemical Properties

Molecular Weight	306.27
Formula	C₁₀H₁₈N₄O₇
Cas No.	2470972-18-8
Smiles	C(C)(O)=O.O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)NC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc