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MTP 131 acetate

Name: MTP 131 acetate
Brand: TargetMol
SKU: T35689
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T35689 Copy Product Info

Purity: 99.9%

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MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.

MTP 131 acetate

Copy Product Info

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Catalog No. T35689

MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.

Cas No. 1334953-95-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$39	In Stock	In Stock
2 mg	$59	In Stock	In Stock
5 mg	$78	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$225	In Stock	In Stock
50 mg	$333	In Stock	In Stock
100 mg	$470	In Stock	In Stock
200 mg	$663	In Stock	-

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

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COA HPLC

Product Introduction

Bioactivity

Description	MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.
In vitro	Pretreatment of cells with MTP 131 (acetate) inhibited H2O2?induced cytotoxicity and reduced LDH release in a dose?dependent manner, compared with cells treated with H2O2 alone. Mitochondrial depolarization and ROS generation were also prevented by MTP 131 (acetate) pretreatment. In addition, MTP 131 (acetate) pretreatment inhibited cytochrome c release from mitochondria to cytoplasm, and significantly reduced apoptosis in RGC?5 cells, compared with cells treated with H2O2 alone[1].
In vivo	18-week-old db/db mice have reduced renal and cardiac superoxide levels, as measured by dihydroethidium oxidation, and increased levels of albuminuria, mesangial matrix accumulation, and urinary H2O2 Administration of MTP 131 (acetate) significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice. MTP 131 (acetate) also reduced total renal lysocardiolipin and major lysocardiolipin subspecies and preserved lysocardiolipin acyltransferase 1 expression in db/db mice[1].

Chemical Properties

Molecular Weight	699.84
Formula	C₃₄H₅₃N₉O₇
Cas No.	1334953-95-5
Smiles	C(C)(O)=O.[C@H](CC1=C(C)C=C(O)C=C1C)(C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N)=O)=O)CCCCN)=O)NC([C@@H](CCCNC(=N)N)N)=O
Relative Density.	no data available
Sequence	Arg-Tyr(2,6-diMe)-Lys-Phe
Sequence Short	RXKF

Storage & Solubility Information

Storage

Keep away from moisture | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 10 mg/mL (14.29 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)

	1mg	5mg	10mg	50mg
1 mM	1.4289 mL	7.1445 mL	14.2890 mL	71.4449 mL
5 mM	0.2858 mL	1.4289 mL	2.8578 mL	14.2890 mL
10 mM	0.1429 mL	0.7144 mL	1.4289 mL	7.1445 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc