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Empasiprubart (Synonyms: ARGX-117)

Catalog No. T82474 Copy Product Info
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Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of C3, demonstrating efficacy in models of complement-mediated autoimmune hemolytic anemia and antibody-mediated organ transplant rejection.

Empasiprubart

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Catalog No. T82474
Synonyms ARGX-117

Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of C3, demonstrating efficacy in models of complement-mediated autoimmune hemolytic anemia and antibody-mediated organ transplant rejection.

Empasiprubart
Cas No. 2579031-19-7
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$247-In Stock
5 mg$622-In Stock
10 mg$996-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:≥95% (SDS-PAGE); 99.12% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of C3, demonstrating efficacy in models of complement-mediated autoimmune hemolytic anemia and antibody-mediated organ transplant rejection.
In vivo
Empasiprubart (200 mg/kg, intravenous injection, single dose) can prevent glial lymphoproliferative disorder damage in GM1 antibody-mediated mouse models. [1]
SynonymsARGX-117
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetComplement C2
Chemical Properties
Molecular Weight~150 kDa
Cas No.2579031-19-7
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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