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Empasiprubart
🥰Excellent
Catalog No. T82474Cas No. 2579031-19-7
Alias ARGX-117
Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of C3, demonstrating efficacy in models of complement-mediated autoimmune hemolytic anemia and antibody-mediated organ transplant rejection.
Empasiprubart
Empasiprubart
🥰Excellent
Purity: 95%
Catalog No. T82474Alias ARGX-117Cas No. 2579031-19-7
Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of C3, demonstrating efficacy in models of complement-mediated autoimmune hemolytic anemia and antibody-mediated organ transplant rejection.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $247 | In Stock | |
| 5 mg | $622 | In Stock | |
| 10 mg | $996 | In Stock |
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Concentration:10.8 mg/mL
Purity:95%
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Product Introduction
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Chemical Properties
| Description | Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of C3, demonstrating efficacy in models of complement-mediated autoimmune hemolytic anemia and antibody-mediated organ transplant rejection. |
| In vivo | Empasiprubart (200 mg/kg, intravenous injection, single dose) can prevent glial lymphoproliferative disorder damage in GM1 antibody-mediated mouse models. [1] |
| Synonyms | ARGX-117 |
| Cas No. | 2579031-19-7 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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