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Empasiprubart
(Synonyms: ARGX-117) Copy Product Info
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Synonyms: ARGX-117
Catalog No. T82474 Copy Product Info
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Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of C3, demonstrating efficacy in models of complement-mediated autoimmune hemolytic anemia and antibody-mediated organ transplant rejection.
Cas No. 2579031-19-7
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $622 | - | In Stock | |
| 10 mg | $996 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:≥95% (SDS-PAGE); 99.12% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Chemical Properties
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| Description | Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody that targets the complement component C2. by binding with high affinity to the Sushi-2 domain of C2, it prevents the formation of the C3 proconvertase complex and thereby inhibits classical and lectin pathway activation upstream of C3, demonstrating efficacy in models of complement-mediated autoimmune hemolytic anemia and antibody-mediated organ transplant rejection. |
| In vivo | Empasiprubart (200 mg/kg, intravenous injection, single dose) can prevent glial lymphoproliferative disorder damage in GM1 antibody-mediated mouse models. [1] |
| Synonyms | ARGX-117 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Complement C2 |
| Molecular Weight | ~150 kDa |
| Cas No. | 2579031-19-7 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Empasiprubart chemical structure | Empasiprubart in vivo | Empasiprubart molecular weight
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