Shopping Cart

Your shopping cart is currently empty

ACBI2

Name: ACBI2
Brand: TargetMol
SKU: T74984
Price: 993 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: ACBI-2, ACBI 2) Copy Product Info

🥰Excellent

Synonyms: ACBI-2, ACBI 2

Catalog No. T74984 Copy Product Info

🥰Excellent

ACBI2 is a highly potent and orally active VHL-recruiting PROTAC (EC50=7 nM) that degrades SMARCA2 (DC50=1 nM in RKO cells). ACBI2 can be used in lung cancer research.

Cas No. 2913161-19-8

Pack Size	Price	USA Stock	Global Stock
1 mg	$247	-	In Stock
5 mg	$619	-	In Stock
10 mg	$993	-	In Stock
25 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	ACBI2 is a highly potent and orally active VHL-recruiting PROTAC (EC50=7 nM) that degrades SMARCA2 (DC50=1 nM in RKO cells). ACBI2 can be used in lung cancer research.
Targets & IC50	VHL:7 nM (EC50), A549:30 nM (GI50)
In vitro	ACBI2 degrades SMARCA2 and SMARCA4 in RKO cells, with DC50s of 1 nM and 32 nM, respectively [1]. ACBI2 (0.1 nM–1 μM, 4–18 hours) rapidly and completely degrades SMARCA2 in two sensitive cell lines (A549 and NCI-H1568) [1]. ACBI2 (1 nM–1 μM, 18 hours) significantly degrades SMARCA2 and exhibits greater selectivity than SMARCA4 [1]. ACBI2 (0–1 μM; 18 hours) degrades SMARCA2 in human whole blood in a dose-dependent manner [1].
In vivo	ACBI2 (80 mg/kg, oral, once daily) significantly inhibited tumor growth in a mouse model of A549 xenografts [1]. ACBI2 (5–100 mg/kg, oral, with tumors harvested 24 or 48 hours after treatment) dose-dependently downregulated SMARCA2 (IHC staining) in A549-bearing mice [1]. The oral bioavailability of ACBI2 (30 mg/kg, oral, in mice) was 22% [1].
Synonyms	ACBI-2, ACBI 2

Chemical Properties

Molecular Weight	1064.16
Formula	C₅₆H₆₈BrFN₈O₅S
Cas No.	2913161-19-8
Smiles	O=C1N=C2N(C=3C(N2C4CCCC4)=CC(=CC3)C5CCN(CC[C@H](CC[C@H](NC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)C(C)(C)C)=O)C[C@H](O)C6)C8=CC=C(C=C8)C9=C(C)N=CS9)C)CC5)C=%10C1=C(Br)C=CC%10

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (93.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9397 mL	4.6985 mL	9.3971 mL	46.9854 mL
5 mM	0.1879 mL	0.9397 mL	1.8794 mL	9.3971 mL
10 mM	0.0940 mL	0.4699 mL	0.9397 mL	4.6985 mL
20 mM	0.0470 mL	0.2349 mL	0.4699 mL	2.3493 mL
50 mM	0.0188 mL	0.0940 mL	0.1879 mL	0.9397 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: ACBI2 chemical structure | ACBI2 in vivo | ACBI2 in vitro | ACBI2 formula | ACBI2 molecular weight