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5-hydroxy Omeprazole

Catalog No. T37659 CAS 92340-57-3

5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]

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5-hydroxy Omeprazole, CAS 92340-57-3

Pack Size	Availability	Price/USD	Quantity
500 μg	35 days	$ 763.00
1 mg	35 days	$ 1,210.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	361.42
Formula	C17H19N3O4S
CAS No.	92340-57-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 2 mg/mL

DMF: 20 mg/mL

DMSO: 10 mg/mL

References and Literature

1. Shi, S., and Klotz, U. Proton pump inhibitors: An update of their clinical use and pharmacokinetics. Eur. J. Clin. Pharmacol. 64(10), 935-951 (2008). 2. Abelö, A., Andersson, T.B., Antonsson, M., et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab. Dispos. 28(8), 966-972 (2000). 3. Karam, W.G., Goldstein, J.A., Lasker, J.M., et al. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab. Dispos. 24, 1081-1087 (1996).

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Keywords

5-hydroxy Omeprazole 92340-57-3 5hydroxy Omeprazole 5 hydroxy Omeprazole inhibitor inhibit

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