Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferation in HaCat cells [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | 8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferation in HaCat cells [1]. |
In vitro | Compound 8A8, at a low concentration (2.5 μM; RAW 264.7 cells), markedly reduced IL-6 and TNF-α levels, achieving half the concentration of these cytokines compared to post-LPS treatment at 5 μM. Furthermore, the levels of IL-6 and TNF-α in cell supernatants were reduced to a quarter following treatment with a high concentration of compound 8A8 (10 μM) [1]. |
Molecular Weight | 799.06 |
Formula | C36H37BrClN5O9 |
CAS No. | 2766594-12-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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8A8 2766594-12-9 Immunology/Inflammation NO Synthase inhibitor inhibit