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3-Hydroxypyridine

Name: 3-Hydroxypyridine
Brand: TargetMol
SKU: T38479
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38479Cas No. 109-00-2

3-Hydroxypyridine exhibits inhibitory activity against DNA topoisomerase 2-beta (Topo IIβ) and HIV-1 replication in Sup-T1 cells, making it useful for studying the HIV-1 virus.

3-Hydroxypyridine

🥰Excellent

Purity: 99.8%

Catalog No. T38479Cas No. 109-00-2

3-Hydroxypyridine exhibits inhibitory activity against DNA topoisomerase 2-beta (Topo IIβ) and HIV-1 replication in Sup-T1 cells, making it useful for studying the HIV-1 virus.

Pack Size	Price	Availability	Quantity
25 g	$29	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.8%

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COA LCMS

Product Introduction

Bioactivity

Description	3-Hydroxypyridine exhibits inhibitory activity against DNA topoisomerase 2-beta (Topo IIβ) and HIV-1 replication in Sup-T1 cells, making it useful for studying the HIV-1 virus.
Targets&IC50	MIA PaCa-2 cells:56480 nM
In vitro	Treatment of HaCaT keratinocytes with 3-Hydroxypyridine (100 μM, 3 days) and subsequent exposure to solar-simulated light inhibited proliferation and induced cell cycle arrest and apoptosis. [1]

Chemical Properties

Molecular Weight	95.1
Formula	C₅H₅NO
Cas No.	109-00-2
Smiles	OC=1C=NC=CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (1051.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (42.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	10.5152 mL	52.5762 mL	105.1525 mL	525.7624 mL
5 mM	2.1030 mL	10.5152 mL	21.0305 mL	105.1525 mL
10 mM	1.0515 mL	5.2576 mL	10.5152 mL	52.5762 mL
20 mM	0.5258 mL	2.6288 mL	5.2576 mL	26.2881 mL
50 mM	0.2103 mL	1.0515 mL	2.1030 mL	10.5152 mL
100 mM	0.1052 mL	0.5258 mL	1.0515 mL	5.2576 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc