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SC 51089

Name: SC 51089
Brand: TargetMol
SKU: T23331
Rating: 4.5 (1 reviews)

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Catalog No. T23331Cas No. 146033-02-5

Alias SC 51089 free base

SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model .

SC 51089

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Catalog No. T23331Alias SC 51089 free baseCas No. 146033-02-5

Pack Size	Price	Availability
1 mg	$293	6-8 weeks
5 mg	$722	6-8 weeks
10 mg	$987	6-8 weeks
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model .
Targets&IC50	EP3:17.5 μM (Ki), TP Receptor:11.2 μM (Ki), FP:61.1 μM (Ki), EP1:1.3 μM (Ki)
In vivo	In the R6/1 mouse model of Huntington's disease (HD), treatment with SC 51089 (40 μg/kg/day; i.p.) for 28 days improved motor coordination and balance deficits, rescued long-term memory loss, as well as improved the expression of specific synaptic markers and reduced the number of intranuclear inclusions of huntingtin protein in the striatum and hippocampus[3].
Synonyms	SC 51089 free base

Chemical Properties

Molecular Weight	459.33
Formula	C₂₂H₂₀Cl₂N₄O₃
Cas No.	146033-02-5
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (189.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1771 mL	10.8854 mL	21.7708 mL	108.8542 mL
5 mM	0.4354 mL	2.1771 mL	4.3542 mL	21.7708 mL
10 mM	0.2177 mL	1.0885 mL	2.1771 mL	10.8854 mL
20 mM	0.1089 mL	0.5443 mL	1.0885 mL	5.4427 mL
50 mM	0.0435 mL	0.2177 mL	0.4354 mL	2.1771 mL
100 mM	0.0218 mL	0.1089 mL	0.2177 mL	1.0885 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc