NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease, and tumors. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. Neurotrimin is a member of the family of neural cell adhesion molecules. Its expression pattern suggests that Ntm promotes axonal fasciculation, guides nerve fibers to specific targets and stabilizes synapses as it accumulates coincident with synaptogenesis. Diseases associated with NTM include Connective Tissue Disease and Jacobsen Syndrome.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | In stock | $ 450.00 | |
200 μg | 5 days | $ 767.00 |
Biological Information | Testing in progress |
Description | NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease, and tumors. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. Neurotrimin is a member of the family of neural cell adhesion molecules. Its expression pattern suggests that Ntm promotes axonal fasciculation, guides nerve fibers to specific targets and stabilizes synapses as it accumulates coincident with synaptogenesis. Diseases associated with NTM include Connective Tissue Disease and Jacobsen Syndrome. |
Species | Human |
Expression System | HEK293 |
Tag | His |
Accession Number | Q9P121-3 |
Synonyms | HNT, NTRI, IGLON2, neurotrimin |
Construction | A DNA sequence encoding the human NTM (NP_001137531.1) (Met1-Gly312) was expressed with a polyhistidine tag at the C-terminus. |
Protein Purity |
> 95 % as determined by SDS-PAGE.
|
Molecular Weight | Approxiamtely 32.3 kDa |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease, and tumors. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. Neurotrimin is a member of the family of neural cell adhesion molecules. Its expression pattern suggests that Ntm promotes axonal fasciculation, guides nerve fibers to specific targets and stabilizes synapses as it accumulates coincident with synaptogenesis. Diseases associated with NTM include Connective Tissue Disease and Jacobsen Syndrome. |
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Please read the User Guide of Recombinant Proteins for more specific information.
HNT/NTM Protein, Human, Recombinant (His) HNT IGLON-2 NTRI IGLON 2 IGLON2 neurotrimin recombinant recombinant-proteins proteins protein