Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Maytansinoid B, an ADC cytotoxin, conjugates with antibodies to create antibody-drug conjugates (ADCs). This antimitotic agent binds to tubulin, inhibiting microtubule assembly, and induces G2/M arrest in the cell cycle, leading to apoptosis [1] [2].
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Description | Maytansinoid B, an ADC cytotoxin, conjugates with antibodies to create antibody-drug conjugates (ADCs). This antimitotic agent binds to tubulin, inhibiting microtubule assembly, and induces G2/M arrest in the cell cycle, leading to apoptosis [1] [2]. |
In vitro | Maytansinoid displays cytotoxic activity in the range of 10-90 pM against several tumor cell lines, including lymphoma [1]. When conjugated with an anti-CD9 antibody, it forms SAR3419, which targets B-cell malignancies [1]. |
Molecular Weight | 735.26 |
Formula | C36H51ClN4O10 |
CAS No. | 1628543-40-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Maytansinoid B 1628543-40-7 inhibitor inhibit