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Mca-(ala7,lys(dnp)9)-bradykinin

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Catalog No. T78435Cas No. 323577-36-2

Mca-(Ala7,Lys(Dnp)9)-bradykinin is a fluorogenic substrate that demonstrates high sensitivity for ECE-1 (endothelin-converting enzyme-1). It features a (7-methoxycoumarin-4-yl)acetyl (Mca) group for fluorescence and a 2,4-dinitrophenyl (Dnp) group for quenching, yielding a significant increase in fluorescence when the substrate is cleaved [1].

Mca-(ala7,lys(dnp)9)-bradykinin

Mca-(ala7,lys(dnp)9)-bradykinin

😃Good
Catalog No. T78435Cas No. 323577-36-2
Mca-(Ala7,Lys(Dnp)9)-bradykinin is a fluorogenic substrate that demonstrates high sensitivity for ECE-1 (endothelin-converting enzyme-1). It features a (7-methoxycoumarin-4-yl)acetyl (Mca) group for fluorescence and a 2,4-dinitrophenyl (Dnp) group for quenching, yielding a significant increase in fluorescence when the substrate is cleaved [1].
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Product Introduction

Bioactivity
Description
Mca-(Ala7,Lys(Dnp)9)-bradykinin is a fluorogenic substrate that demonstrates high sensitivity for ECE-1 (endothelin-converting enzyme-1). It features a (7-methoxycoumarin-4-yl)acetyl (Mca) group for fluorescence and a 2,4-dinitrophenyl (Dnp) group for quenching, yielding a significant increase in fluorescence when the substrate is cleaved [1].
In vitro
Mca-Ala7,Lys(Dnp)9-Bradykinin serves as a substrate for neprilysin; however, it is hydrolyzed by ECE-1 with tenfold greater efficiency, indicating a selectivity for ECE-1 [1].
Chemical Properties
Molecular Weight1388.44
FormulaC66H81N15O19
Cas No.323577-36-2
SmilesC(C(N[C@H](C(=O)N1[C@H](C(=O)N2[C@H](C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCNC5=C(N(=O)=O)C=C(N(=O)=O)C=C5)C(O)=O)=O)=O)C)=O)CO)=O)=O)=O)CCC2)CCC1)CCCNC(=N)N)=O)C=6C=7C(=CC(OC)=CC7)OC(=O)C6
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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