SARS-CoV-2 3CLpro-IN-5

Name: SARS-CoV-2 3CLpro-IN-5
Brand: TargetMol
SKU: T72364
Rating: 4.5 (1 reviews)

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Catalog No. T72364Cas No. 2913186-57-7

SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), with potent inhibitory activity (IC50: 3.8 nM) and 9.0% oral bioavailability (BA), used in COVID-19 research [1].

SARS-CoV-2 3CLpro-IN-5

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Catalog No. T72364Cas No. 2913186-57-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	8-10 weeks	8-10 weeks
50 mg	$1,980	8-10 weeks	8-10 weeks
100 mg	$2,500	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), with potent inhibitory activity (IC50: 3.8 nM) and 9.0% oral bioavailability (BA), used in COVID-19 research [1].
In vitro	SARS-CoV-2 3CLpro-IN-5 demonstrates inhibitory activity against 3CL protease with an IC50 of 3.8 nM [1], and antiviral effects against SARS-CoV-2 variants (Alpha, Delta, Omicron BA.1, BA.2) in 293TAT cells, with EC50 values of 13.8 nM, 7.57 nM, 9.01 nM, and 17.1 nM, respectively [1]. It also shows activity against other coronaviruses: SARS-CoV (EC50 59.3 nM), MERS-CoV in 293TDPP4 cells (EC50 4.72 nM), and HCoV-OC43 (EC50 1.67 nM) [1].
In vivo	SARS-CoV-2 3CLpro-IN-5, when administered orally or intravenously at dosages of 10 or 100 mg/kg, exhibits potent antiviral effects and possesses advantageous pharmacokinetic properties [1].

Chemical Properties

Molecular Weight	497.92
Formula	C₂₂H₂₆ClF₂N₅O₄
Cas No.	2913186-57-7
Smiles	#N/A

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc