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Pozanicline hydrochloride

Name: Pozanicline hydrochloride
Brand: TargetMol
SKU: T16563L
Price: 70 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16563L

Pozanicline hydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline hydrochloride is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2].

Pozanicline hydrochloride

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Purity: 99.81%

Catalog No. T16563L

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$70	-	In Stock
5 mg	$157	-	In Stock
10 mg	$232	-	In Stock
25 mg	$355	-	In Stock
50 mg	$497	-	In Stock
100 mg	$666	-	In Stock
200 mg	$898	-	In Stock
1 mL x 10 mM (in DMSO)	$136	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pozanicline hydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline hydrochloride is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2].
In vitro	Pozanicline hydrochloride is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC50 of 0.11 μM[2]. Pozanicline hydrochloride shows high selectivity for α6β2 and α4α5β2 nAChR subtypes[3].
In vivo	Pozanicline hydrochloride (0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning[3].

Chemical Properties

Molecular Weight	228.72
Formula	C₁₁H₁₇ClN₂O
Smiles	[H]Cl.CC1=NC=CC=C1OC[C@H]2NCCC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (240.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3722 mL	21.8608 mL	43.7216 mL	218.6079 mL
5 mM	0.8744 mL	4.3722 mL	8.7443 mL	43.7216 mL
10 mM	0.4372 mL	2.1861 mL	4.3722 mL	21.8608 mL
20 mM	0.2186 mL	1.0930 mL	2.1861 mL	10.9304 mL
50 mM	0.0874 mL	0.4372 mL	0.8744 mL	4.3722 mL
100 mM	0.0437 mL	0.2186 mL	0.4372 mL	2.1861 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc