This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
AR-R 17779 hydrochloride
Catalog No. T21857 CAS
178419-42-6
AR-R17779 hydrochloride is a potent, selective full agonist of the nAChR, demonstrating K i values of 92 nM for the α7 subtype and 16,000 nM for the α4β2 subtype. It is noted for its ability to enhance learning and memory in rats, suggesting potential therapeutic applications. Additionally, this compound exhibits anxiolytic properties and can mitigate inflammation by activating anti-inflammatory cholinergic (vagal) pathways [1] [2] [4].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
AR-R17779 hydrochloride is a potent, selective full agonist of the nAChR, demonstrating K i values of 92 nM for the α7 subtype and 16,000 nM for the α4β2 subtype. It is noted for its ability to enhance learning and memory in rats, suggesting potential therapeutic applications. Additionally, this compound exhibits anxiolytic properties and can mitigate inflammation by activating anti-inflammatory cholinergic (vagal) pathways [1] [2] [4].
In vitro
AR-R17779 demonstrates a fivefold increase in potency and is 35,000 times more selective for the α7 nicotinic receptor than (-)-nicotine [1]. Additionally, when applied at a concentration of 200 nM for 24 hours, AR-R17779 effectively inhibits LPS-induced TNF production in macrophages [4].
In vivo
AR-R17779, administered intraperitoneally (i.p.) at doses of 1-5 mg/kg twice daily for 7 days, has been shown to improve arthritis symptoms, reduce synovial inflammation, delay the onset of the disease, and protect against joint destruction in male DBA/1 mice aged 8-10 weeks. This compound, when given subcutaneously (s.c.) at 1-10 mg/kg for 3 weeks, also enhances learning in two radial-arm maze tasks and reverses working memory impairments in rats with fimbria-fornix sections. Notably, in an animal model where arthritis was induced with type II collagen following unilateral cervical vagotomy or sham surgery, doses of 1, 2.5, and 5 mg/kg administered i.p. twice daily from day 20 to day 26 led to amelioration of arthritis, delayed disease onset, and reductions in erosive disease, cartilage degradation, synovial inflammation, and TNFα levels in both plasma and synovial tissue.
Molecular Weight
218.68
Formula
C9H15ClN2O2
CAS No.
178419-42-6
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.