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8-CPT-2'-O-Me-cAMP
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Catalog No. T88612Cas No. 510774-50-2
8-CPT-2'-O-Me-cAMP (250 µM; 1 h) induces Rap1 activation and enhances the recruitment of junction proteins and cortical F-actin in retinal pigment epithelial cells.
8-CPT-2'-O-Me-cAMP
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Catalog No. T88612Cas No. 510774-50-2
8-CPT-2'-O-Me-cAMP (250 µM; 1 h) induces Rap1 activation and enhances the recruitment of junction proteins and cortical F-actin in retinal pigment epithelial cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 4-6 weeks | 4-6 weeks | |
| 50 mg | $1,980 | 4-6 weeks | 4-6 weeks | |
| 100 mg | $2,500 | 4-6 weeks | 4-6 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | 8-CPT-2'-O-Me-cAMP (250 µM; 1 h) induces Rap1 activation and enhances the recruitment of junction proteins and cortical F-actin in retinal pigment epithelial cells. |
| In vitro | 8-CPT-2'-O-Me-cAMP (250 µM; 1 h) induces Rap1 activation and enhances the recruitment of junction proteins and cortical F-actin in retinal pigment epithelial cells. |
| In vivo | The chemical compound 8-CPT-2'-O-Me-cAMP, administered through a 1 µL intravitreal injection at a concentration of 2.05µM, shows efficacy in hindering the progression of choroidal neovascular lesions in a laser-induced damage model. Utilizing a cnoroidal neovascularization (CNV) model in wild type (WT) C57/Bl6 mice, the assigned dosage and administration method resulted in a dose-dependent reduction in CNV volume and an elevation in Rap1 activity within isolated RPE/choroids. Furthermore, the treatment induced a noticeable augmentation in F-actin localization towards the cell periphery and led to a reorganization of the cell junctions into a more linear configuration. |
| Molecular Weight | 485.84 |
| Formula | C17H17ClN5O6PS |
| Cas No. | 510774-50-2 |
| Smiles | S(C=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](OC)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H])C5=CC=C(Cl)C=C5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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