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Isoangustone A
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Catalog No. TN4263Cas No. 129280-34-8
Isoangustone A is a natural product that inhibits PI3K, MKK4, and MKK7 through ATP competition, suppresses the expression of G1 phase regulatory proteins, inhibits the phosphorylation of Akt, GSK-3β, and JNK1/2, and inhibits the proliferation of human melanoma cells and tumour growth in xenograft mouse models.
Isoangustone A
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Purity: 98.89%
Catalog No. TN4263Cas No. 129280-34-8
Isoangustone A is a natural product that inhibits PI3K, MKK4, and MKK7 through ATP competition, suppresses the expression of G1 phase regulatory proteins, inhibits the phosphorylation of Akt, GSK-3β, and JNK1/2, and inhibits the proliferation of human melanoma cells and tumour growth in xenograft mouse models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $229 | - | In Stock | |
| 5 mg | $577 | - | In Stock | |
| 10 mg | $822 | - | In Stock | |
| 25 mg | $1,230 | - | In Stock | |
| 50 mg | $1,680 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.89%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Isoangustone A is a natural product that inhibits PI3K, MKK4, and MKK7 through ATP competition, suppresses the expression of G1 phase regulatory proteins, inhibits the phosphorylation of Akt, GSK-3β, and JNK1/2, and inhibits the proliferation of human melanoma cells and tumour growth in xenograft mouse models. |
| In vitro | Method: A cell proliferation assay was performed using the SK-MEL-28 cell line. Cells were treated with Isoangustone A at concentrations of 10 μM and 20 μM for 48 and 72 hours to evaluate its effect on cell proliferation. Result: Isoangustone A significantly inhibited the proliferation of SK-MEL-28 cells in a dose- and time-dependent manner. [1] |
| In vivo | Method: A SK-MEL-28 xenograft tumor model was established using male Balb/c nude (nu/nu) mice. Mice were administered Isoangustone A via daily intraperitoneal injection at doses of 2 or 10 mg/kg for 35 consecutive days to evaluate its antitumor effects. Result: Isoangustone A significantly reduced tumor weight compared to the control group. It also markedly decreased the expression of proliferating cell nuclear antigen (PCNA) and reduced the phosphorylation levels of Akt. [1] |
| Molecular Weight | 422.47 |
| Formula | C25H26O6 |
| Cas No. | 129280-34-8 |
| Smiles | O=C1C(=COC2=CC(O)=C(C(O)=C12)CC=C(C)C)C=3C=C(O)C(O)=C(C3)CC=C(C)C |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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