This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
R-PSOP
Catalog No. T61210 CAS
1185189-97-2
R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous system (CNS) penetration and is valuable in the study of eating disorders, obesity, pain, and stress-related disorders [1].
All TargetMol products are for research or drug registration purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose in violation of laws and regulations.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Contact us for more batch information
Biological Description
Chemical Properties
Storage
& Solubility Information
Description
R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous system (CNS) penetration and is valuable in the study of eating disorders, obesity, pain, and stress-related disorders [1].
In vitro
According to Schild analyses, R-PSOP exhibits functional K_b values of 92 nM for human NMUR2 and 155 nM for rat NMUR2, highlighting its inhibitory effect on intracellular calcium mobilization triggered by NMU-25 in HEK293 cells expressing NMUR2 (the effects of R-PSOP on intracellular calcium mobilization induced by NMU-25 in HEK293 cells expressing human or rat NMUR2) [1]. Furthermore, R-PSOP effectively suppresses the activity initiated by peptide agonists NMU-25, NMU-23, and NMU-8 in these cells. The compound also concentration-dependently diminishes phosphoinositide (PI) turnover stimulated by 10 nM NMU-25 in cells expressing human NMUR2, showing an EC_50 of 5 nM and an IC_50 value of 86 nM [1]. These findings underscore R-PSOP's potent inhibitory effects on specific biochemical responses in human embryonic kidney 293 cells expressing NMUR2.
In vivo
R-PSOP (10 μL 50 nmol; intrathecal injection; male Sprague-Dawley rats) reduces nociceptive responses triggered by NMU-23 in a spinal reflex setup in male Sprague-Dawley rats, indicating its analgesic potential [1].
Molecular Weight
350.41
Formula
C20H22N4O2
CAS No.
1185189-97-2
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
More
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculator
Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
bottom
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.