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AZ5385
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Catalog No. T85781Cas No. 848439-89-4
AZ5385 functions as an EGFR-tyrosine kinase inhibitor and also acts as a blocker of the HRV-2 virus, with an EC 50 value of 0.35 µM. It impacts the late stage of the viral life cycle [1].
AZ5385
😃Good
Catalog No. T85781Cas No. 848439-89-4
AZ5385 functions as an EGFR-tyrosine kinase inhibitor and also acts as a blocker of the HRV-2 virus, with an EC 50 value of 0.35 µM. It impacts the late stage of the viral life cycle [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | AZ5385 functions as an EGFR-tyrosine kinase inhibitor and also acts as a blocker of the HRV-2 virus, with an EC 50 value of 0.35 µM. It impacts the late stage of the viral life cycle [1]. |
| In vitro | AZ5385 has a CC50 of 9 µM against HeLa cells over 72 hours [1]. When AZ5385 is pre-incubated for 3 hours before viral addition and then co-incubated with the virus at 37°C for 72 hours, it inhibits the infection of HEp-2 cells by HRV-16 and RSV A2 strains, with EC50 values of 3.6 µM and 0.4 µM, respectively [1]. |
| Molecular Weight | 460.89 |
| Formula | C22H22ClFN4O4 |
| Cas No. | 848439-89-4 |
| Smiles | N(C=1C2=C(C=C(OC3CCN(C([C@H](C)O)=O)CC3)C(O)=C2)N=CN1)C4=C(F)C(Cl)=CC=C4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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