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Koshidacin B, a cyclic tetrapeptide, exhibits potent antiplasmodial activity, evidenced by its ability to inhibit Plasmodium falciparum strains FCR3 and K1 with IC50 values of 0.89 μM and 0.83 μM, respectively. It has been shown to effectively suppress malaria parasites in vivo and has potential applications in parasitic infection research [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks | 8-10 weeks |
| Description | Koshidacin B, a cyclic tetrapeptide, exhibits potent antiplasmodial activity, evidenced by its ability to inhibit Plasmodium falciparum strains FCR3 and K1 with IC50 values of 0.89 μM and 0.83 μM, respectively. It has been shown to effectively suppress malaria parasites in vivo and has potential applications in parasitic infection research [1]. |
| In vitro | Koshidacin B exhibits antiplasmodial properties, efficacious against both chloroquine-sensitive P. falciparum FCR3 and chloroquine-resistant P. falciparum K1 strains, presenting IC50 values of 0.89 μM and 0.83 μM after a 72-hour exposure, respectively [1]. Additionally, a 7-day exposure to Koshidacin B reveals cytotoxic effects on human MRC-5 cells with an IC50 of 14.7 μM [1]. |
| In vivo | Koshidacin B, administered intraperitoneally at a dosage of 30 mg/kg once daily over a four-day period, exhibits in vivo antiplasmodial activity [1]. |
| Molecular Weight | 544.64 |
| Formula | C28H40N4O7 |
| Cas No. | 2925302-01-6 |
| Smiles | #N/A |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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