Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies. This compound exhibits potent activity, with degradation concentration half-maximal (DC50) values of 0.23 nM and 0.38 nM for the respective conjugations [1].
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50 mg | Inquiry | Inquiry |
Description | PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies. This compound exhibits potent activity, with degradation concentration half-maximal (DC50) values of 0.23 nM and 0.38 nM for the respective conjugations [1]. |
Molecular Weight | 1292.56 |
Formula | C61H75F2N9O12S4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PROTAC BRD4 Degrader-11 Others inhibitor inhibit