Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PP-C8, a potent and selective PROTAC CDK12-Cyclin K degrader, efficiently induces degradation of CDK12 and Cyclin K, with DC50 values of 416 nM and 412 nM, respectively. This compound exhibits significant synergistic antiproliferative effects when combined with a PARP inhibitor in triple-negative breast cancer (TNBC) [1].
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50 mg | Inquiry | Inquiry |
Description | PP-C8, a potent and selective PROTAC CDK12-Cyclin K degrader, efficiently induces degradation of CDK12 and Cyclin K, with DC50 values of 416 nM and 412 nM, respectively. This compound exhibits significant synergistic antiproliferative effects when combined with a PARP inhibitor in triple-negative breast cancer (TNBC) [1]. |
Molecular Weight | 866.94 |
Formula | C43H51FN12O7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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