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2-Isopropylmalic acid

🥰Excellent
Catalog No. TN6937Cas No. 3237-44-3
Alias α-Isopropylmalate, α-IPM, 2-hydroxy-2-(propan-2-yl)butanedioic acid

2-Isopropylmalic acid (α-Isopropylmalate) inhibits excess reactive oxygen species (ROS) production and stress kinase activation in PM2. 5-treated dermal fibroblasts, promotes primary ciliogenesis and restores PM2. 5-induced primary ciliogenesis hypoplasia in dermal fibroblasts.

2-Isopropylmalic acid

2-Isopropylmalic acid

🥰Excellent
Purity: 99.77%
Catalog No. TN6937Alias α-Isopropylmalate, α-IPM, 2-hydroxy-2-(propan-2-yl)butanedioic acidCas No. 3237-44-3
2-Isopropylmalic acid (α-Isopropylmalate) inhibits excess reactive oxygen species (ROS) production and stress kinase activation in PM2. 5-treated dermal fibroblasts, promotes primary ciliogenesis and restores PM2. 5-induced primary ciliogenesis hypoplasia in dermal fibroblasts.
Pack SizePriceAvailabilityQuantity
2 mg$32In Stock
5 mg$50In Stock
10 mg$85In Stock
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Purity:99.77%
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Product Introduction

Bioactivity
Description
2-Isopropylmalic acid (α-Isopropylmalate) inhibits excess reactive oxygen species (ROS) production and stress kinase activation in PM2. 5-treated dermal fibroblasts, promotes primary ciliogenesis and restores PM2. 5-induced primary ciliogenesis hypoplasia in dermal fibroblasts.
In vitro
500 μM 2-Isopropylmalic acid promoted LEU3 protein (Leu3p)-dependent transcriptional activity.[1]
In preadipocytes (30A5), 10 mM 2-Isopropylmalic acid elevated the expression level of the reporter gene after 48 hours of action. [2]
Synonymsα-Isopropylmalate, α-IPM, 2-hydroxy-2-(propan-2-yl)butanedioic acid
Chemical Properties
Molecular Weight176.17
FormulaC7H12O5
Cas No.3237-44-3
SmilesO=C(O)CC(O)(C(=O)O)C(C)C
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 200 mg/mL (1135.27 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM5.6763 mL28.3817 mL56.7634 mL283.8168 mL
5 mM1.1353 mL5.6763 mL11.3527 mL56.7634 mL
10 mM0.5676 mL2.8382 mL5.6763 mL28.3817 mL
20 mM0.2838 mL1.4191 mL2.8382 mL14.1908 mL
50 mM0.1135 mL0.5676 mL1.1353 mL5.6763 mL
100 mM0.0568 mL0.2838 mL0.5676 mL2.8382 mL

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Keywords

2-Isopropylmalic acid2Isopropylmalic acid2 Isopropylmalic acid
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