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2-Isopropylmalic acid

Name: 2-Isopropylmalic acid
Brand: TargetMol
SKU: TN6937
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6937Cas No. 3237-44-3

Alias α-Isopropylmalate, α-IPM, 2-hydroxy-2-(propan-2-yl)butanedioic acid

2-Isopropylmalic acid (α-Isopropylmalate) inhibits excess reactive oxygen species (ROS) production and stress kinase activation in PM2. 5-treated dermal fibroblasts, promotes primary ciliogenesis and restores PM2. 5-induced primary ciliogenesis hypoplasia in dermal fibroblasts.

2-Isopropylmalic acid

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Purity: 99.93%

Catalog No. TN6937Alias α-Isopropylmalate, α-IPM, 2-hydroxy-2-(propan-2-yl)butanedioic acidCas No. 3237-44-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$32	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$70	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-Isopropylmalic acid (α-Isopropylmalate) inhibits excess reactive oxygen species (ROS) production and stress kinase activation in PM2. 5-treated dermal fibroblasts, promotes primary ciliogenesis and restores PM2. 5-induced primary ciliogenesis hypoplasia in dermal fibroblasts.
In vitro	500 μM 2-Isopropylmalic acid promoted LEU3 protein (Leu3p)-dependent transcriptional activity.[1] In preadipocytes (30A5), 10 mM 2-Isopropylmalic acid elevated the expression level of the reporter gene after 48 hours of action. [2]
Synonyms	α-Isopropylmalate, α-IPM, 2-hydroxy-2-(propan-2-yl)butanedioic acid

Chemical Properties

Molecular Weight	176.17
Formula	C₇H₁₂O₅
Cas No.	3237-44-3
Smiles	O=C(O)CC(O)(C(=O)O)C(C)C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 200 mg/mL (1135.27 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.6763 mL	28.3817 mL	56.7634 mL	283.8168 mL
5 mM	1.1353 mL	5.6763 mL	11.3527 mL	56.7634 mL
10 mM	0.5676 mL	2.8382 mL	5.6763 mL	28.3817 mL
20 mM	0.2838 mL	1.4191 mL	2.8382 mL	14.1908 mL
50 mM	0.1135 mL	0.5676 mL	1.1353 mL	5.6763 mL
100 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8382 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc