Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated neurons. Moreover, GM1 influences neuronal plasticity, repair mechanisms, and neurotrophin release in the brain [1] [2].
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Description | Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated neurons. Moreover, GM1 influences neuronal plasticity, repair mechanisms, and neurotrophin release in the brain [1] [2]. |
In vitro | Gangliotetraose (GM1) (10 μM; 1 h) enhances pheochromocytoma PC12 cell survival under oxidative stress induced by hydrogen peroxide (1 mM; 2 h), concurrently reducing reactive oxygen species buildup and preventing oxidative inactivation of the Na+, K+-ATPase enzyme [3]. |
In vivo | Administered intraperitoneally at a dosage of 30 mg/kg on days 5, 11, 42, and 73, Gangliotetraose (GM1) promotes the regrowth of nigrostriatal dopaminergic neurons within the rat central nervous system following unilateral hemitransection [5]. |
Synonyms | Gg4 |
Molecular Weight | 707.63 |
Formula | C26H45NO21 |
CAS No. | 75645-24-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Gangliotetraose 75645-24-8 Gg4 inhibitor inhibit