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CTLA-4 Protein, Cynomolgus/Rhesus, Recombinant (His)
(Synonyms: cytotoxic T-lymphocyte-associated protein 4) Copy Product InfoSynonyms: cytotoxic T-lymphocyte-associated protein 4
Catalog No. TMPY-03589 Copy Product Info
CTLA4 Protein, Cynomolgus/Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is Q9BDC4.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $34 | 7-10 days | 7-10 days | |
| 10 µg | $49 | 7-10 days | 7-10 days | |
| 20 µg | $79 | 7-10 days | 7-10 days | |
| 50 µg | $155 | 7-10 days | 7-10 days | |
| 100 µg | $296 | 7-10 days | 7-10 days | |
| 200 µg | $450 | 7-10 days | 7-10 days | |
| 500 µg | $948 | 7-10 days | 7-10 days | |
| 1 mg | $1,930 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Cynomolgus CTLA-4, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Cynomolgus B7-1, hFc Tag with the EC50 of 7.4 ng/ml determined by ELISA (QC Test). Immobilized Cynomolgus CTLA-4, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-CTLA-4 Antibody, hFc Tag with the EC50 of 11.2 ng/ml determined by ELISA. Cynomolgus B7-1, His Tag immobilized on CM5 Chip can bind Cynomolgus CTLA-4, His Tag with an affinity constant of 9.90 nM as determined in SPR assay (Biacore T200). |
| Description | CTLA4 Protein, Cynomolgus/Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is Q9BDC4. |
| Species | Cynomolgus,Rhesus |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | G7PL88-1 |
| Construction | Ala37-Ser160 |
| Protein Purity | > 95 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Synonyms | cytotoxic T-lymphocyte-associated protein 4 |
| Research Background | Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsCTLA4 / CD152 Immune Checkpoint ProteinsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Molecular Weight | 14.4 kDa (predicted); 25-30 kDa (reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: CTLA-4 Protein, Cynomolgus/Rhesus, Recombinant (His) chemical structure | CTLA-4 Protein, Cynomolgus/Rhesus, Recombinant (His) molecular weight
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