Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM. While not directly inhibiting tumor cell growth, PPM-3 affects tumor progression through influencing macrophage differentiation [1].
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Description | PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM. While not directly inhibiting tumor cell growth, PPM-3 affects tumor progression through influencing macrophage differentiation [1]. |
Targets&IC50 | ERK5:62.4 nM |
In vitro | PPM-3, applied at a concentration of 200 nM for 0-72 hours to A375 cells, initiates ERK5 degradation within 2-4 hours, with peak degradation observed at 12 hours and sustained for at least 72 hours [1]. Additionally, PPM-3, ranging from 0-1 μM for 12 hours, exhibits ERK5 degradation activity in various cancer cell lines—H1975, HepG2, MDA-MB-231, PC-3, HCT116, and A375—with respective DC50 values of 11.5±2.5, 13.7±8.2, 22.7±13.3, 23.5±10.3, 5.6±1.9, and 41.4±22.3 nM [1]. |
Molecular Weight | 1000.26 |
Formula | C54H69N11O6S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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PPM-3 PROTAC PROTACs inhibitor inhibit